Trey Hedden, PhD

Title: Assistant in Neuroscience, MGH/HST Athinoula A. Martinos Center for Biomedical Imaging & Assistant Professor of Radiology, Harvard Medical School
Telephone: (617) 643-5529

Dr. Hedden is an Assistant Professor in Radiology at Harvard Medical School and the Athinoula A. Martinos Center for Biomedical Imaging at Massachusetts General Hospital. He is an Investigator for the Harvard Aging Brain Study ( and the Massachusetts Alzheimer's Disease Research Center. His research focuses on applying innovative neuroimaging techniques to aging and age-related neurodegenerative disorders. He hosts the Brain Aging Neuroimaging Group seminar series (


Dr. Hedden trained in Cognitive Science (B.A.; University of Virginia), Cognitive Psychology (Ph.D.; University of Michigan), and Cognitive Neuroscience (Postdoctoral Fellow; Stanford University, MIT, and Harvard

University) prior to joining Massachusetts General Hospital in 2008.


Dr. Hedden's research uses innovative multi-modal neuroimaging techniques (structural and functional MRI, diffusion imaging, and PET biomarkers) to improve diagnosis and prediction of the likelihood that older individuals will develop age-related or pathogenic neurodegeneration.


Hedden, T. & Gabrieli, J. D. E. (2004).  Insights into the ageing mind: A view from cognitive neuroscience.  Nat Rev Neurosci, 5, 87-96.


Hedden, T, Van Dijk, KRA, Becker, JA, Mehta, A, Sperling, RA, Johnson, KA, Buckner, RL. Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden. Journal of Neurosci, 2009; 29, 12686-12694. [PMCID:  2808119].


Van Dijk, KR, Hedden, T, Venkataraman, A, Evans, KC, Lazar, SW, Buckner, RL. Intrinsic Functional Connectivity as a Tool for Human Connectomics: Theory, Properties, and Optimization. Journal of Neurophysiol 2010; 103, 297-321. [PMCID:  334843].


Hedden, T, Mormino, EC, Amariglio, RE, Younger, AP, Schultz, AP, Becker, JA, Buckner, RL, Johnson, KA, Sperling, RA, Rentz, DM. Cognitive Profile of Amyloid Burden and White Matter Hyperintensities in Cognitively Normal Older Adults. Journal of Neurosci 2012; 32, 16233-16242. [PMCID:  3523110].


Hedden, T, Van Dijk, KRA, Shire, EH, Sperling, RA, Johnson, KA, Buckner, RL. Failure to Modulate Attentional Control in Advanced Aging Linked to White Matter Pathology. Cerebral Cortex 2012; 22, 1038-1051. [PMCID:  3328340].


Hedden, T, Oh, H, Younger, AP, Patel, TA. Meta-Analysis of Amyloid-Cognition Relations in Cognitively Normal Older Adults. Neurology 2013; 80, 1341-1348. [PMCID:  36556457].


Hedden, T, Schultz, AP, Rieckmann, A, Mormino, EC, Johnson, KA, Sperling, RA, Buckner, RL. Multiple Brain Markers are Linked to Age-Related Variation in Cognition. Cerebral Cortex 2014; doi: 10.1093/cercor/bhu238. [PMC Journal - In Process].


Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP. Harvard Aging Brain Study: Dataset and Accessibility. Neuroimage 2015; S1053-8119 (15)00265-7. [PMC Journal - In Process].


Shaw EE, Schultz AP, Sperling R, Hedden T. Functional Connectivity in Multiple Cortical Networks is associated with Performance Across Cognitive Domains in Older Adults. Brain Connect 2015; 5:  505-516. [PMCID:  4601675].


More publications may be found at