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Science Daily (October 15, 2009): Scientists Remove Amyloid Plaques from Brains of Live Animals with Alzheimer's Disease
A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's disease that actually removes amyloid plaques - considered a hallmark of the disease - from patients' brains.
This discovery, published online in the FASEB Journal, is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove plaques instead of causing them or making them worse. The research was performed in a model of Alzheimer's disease established in mice.
"Our study highlights the notion that manipulating the brain's immune response could be translated into clinically tolerated regimens for the treatment of neurodegenerative diseases," said Pritam Das, co-author of the study, from the Mayo Clinic in Jackonville, FL.