Science Daily (November 2, 2009): High Blood Pressure and Markers of Inflammation in Blood Mice Common in Offspring of Parents with Alzheimer's Disease

Publication Date: 
Mon, 11/02/2009

High blood pressume, evidence of arterial disease and markers of inflammation in the blood in middle age appear more common in inidividuals whose parents have Alzheimer's disease than in individuals without a parental history of the condition, according to a report in the November issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Previous twin studies estimate that as much as 60 percent of the risk for Alzheimer's idsease is under genetic control, according to background information in the article. Other research has identified several vascular and inflammatory risk factors in midlife that may be associated with the later transition into cognitive decline related to Alzheimer's disease.

Eric van Exel, MD, PhD, of VU University Medical Center, Amsterdam, and colleagues compared some of these vascular and inflammatory factors, such as high blood pressue and levels of pro-inflammatory proteins known as cytokines in the blood,between 206 offspring of 92 families with a history of Alzheimer's disease and 200 offspring of 97 families without a parental history.