Reisa A. Sperling, MD, MMSc
Reisa Sperling, M.D., M.MSc. is a neurologist, specializing in dementia and imaging research. She is an Associate Professor in Neurology at the Harvard Medical School. Dr. Sperling is also the Director of the Center for Alzheimer's Research and Treatment, and the Director of Clinical Research, Memory Disorders Unit, Brigham and Women's Hospital. She leads an active Alzheimer's disease clinical trial program across the Massachusetts General Hospital and the Brigham and Women's Hospital.
Dr. Sperling serves as the Co-Director of the Neuroimaging Program, the Information & Education Transfer Core of the Massachusetts Alzheimer's Disease Research Center, and is a member of the Gerontology Research Unit at the Massachusetts General Hospital. She is past chair of the Medical and Scientific Advisory Committee of the Massachusetts Chapter of the Alzheimer's Association, and currently serves on the Steering Committee for the National Institutes of Health Alzheimer's Disease Cooperative Study and Alzheimer's Disease Neuroimaging Initiative.
Dr. Sperling's research is focused on the early diagnosis and treatment of Alzheimer's disease. Her recent work involves the use of functional MRI and PET amyloid imaging to study alterations in brain function during in aging and early Alzheimer's disease. She is the Principal Investigator on multiple NIH and Foundation grants to study the neural basis of memory impairment in MCI and AD, and the relationship of amyloid deposition to memory function.
Dr. Sperling has received the American Academy of the Neurology Clinical Research Fellowship Award, the Harvard Medical School Scholars in Medicine Fellowship, the Alzheimer's Association Memory Ride Award, a Paul Beeson Faculty Scholars in Aging Award, and the 2007 American Academy of Neurology Research in Geriatric Neurology Award.
Miller SL, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamäki M, Sperling RA. Age-Related Memory Impairment associated with Loss of Parietal Deactivation but Preserved Hippocampal Activation. Proc Natl Acad Sci USA 2008; 105: 2181-2196. [PMCID: 2538895].
Buckner R, Sepulcre J, Talukdar T, Krienen F, Liu H, Hedden T, Andrews-Hanna J, Sperling R, Johnson K. Cortical Hubs Revealed by Intrinsic Functional Connectivity: Mapping, Assessment of Stability, and Relation to Alzheimer's Disease. J Neurosci 2009; 29: 1860-1873. [PMCID: 2750039].
Chua EF, Schacter DL, Sperling RA. Neural Basis for Recognition Confidence in Younger and Older Adults. Psychology and Aging 2009; 24: 139-153. [PMCID: 2657923].
Salloway SP, Sperling RA, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M, Honig LS, Doody R, van Dyck C, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg I, Schenk D, Black R, Grundman M. A Phase 2 Multiple Ascending Dose Trial of Bapineuzumab in Mild to Moderate Alzheimer's Disease. Neurology 2009; 73: 2052-2053. [PMCID: 2790221].
Sperling RA, LaViolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DS, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid Deposition is associated with Impaired Default Network Function in Older Persons without Dementia. Neuron 2009; 63: 178-188. [PMCID: 2738994].
Pihlajamäki M, O'Keefe K, Bertram L, Tanzi R, Dickerson B, Blacker D, Albert M, Sperling RA. Evidence of Altered Posteromedial Cortical fMRI Activity in Subjects at Risk for Alzheimer Disease. Alzheimer Dis Assoc Diord 2010; 24: 28-36. [PMCID: 2837131].
More publications may be found at www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed