|Title||Instrumental activities of daily living impairment is associated with increased amyloid burden.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Marshall, GA, Olson, LE, Frey, MT, Maye, J, J Becker, A, Rentz, DM, Sperling, RA, Johnson, KA|
|Journal||Dement Geriatr Cogn Disord|
|Keywords||Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Amyloidosis, Aniline Compounds, Body Burden, Data Interpretation, Statistical, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Positron-Emission Tomography, Regression Analysis, Surveys and Questionnaires, Temporal Lobe, Thiazoles|
BACKGROUND/AIMS: Instrumental activities of daily living (IADL) impairment in Alzheimer's disease has been associated with global amyloid deposition in postmortem studies. We sought to determine whether IADL impairment is associated with increased cortical Pittsburgh Compound B (PiB) retention.
METHODS: Fifty-five subjects (19 normal older controls, NC, and 36 with mild cognitive impairment, MCI) underwent clinical assessments and dynamic PiB positron emission tomography imaging.
RESULTS: A linear multiple regression model showed that greater IADL impairment was associated with greater global PiB retention in all subjects (R(2) = 0.40; unstandardized partial regression coefficient, β = 5.8; p = 0.0002) and in MCI subjects only (R(2) = 0.28; β = 6.1; p = 0.003), but not in NC subjects only.
CONCLUSION: These results suggest that daily functional impairment is related to greater amyloid burden in MCI.
|Alternate Journal||Dement Geriatr Cogn Disord|
|PubMed Central ID||PMC3150869|
|Grant List||1K23AG033634 / AG / NIA NIH HHS / United States |
K01 AG030514 / AG / NIA NIH HHS / United States
K23 AG033634 / AG / NIA NIH HHS / United States
K24 AG035007 / AG / NIA NIH HHS / United States
P30 AG010129 / AG / NIA NIH HHS / United States
P50 AG005134 / AG / NIA NIH HHS / United States
R01 AG027435S / AG / NIA NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States