|Title||Antisaccade task reflects cortical involvement in mild cognitive impairment.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Heuer, HW, Mirsky, JB, Kong, EL, Dickerson, BC, Miller, BL, Kramer, JH, Boxer, AL|
|Date Published||2013 Oct 1|
|Keywords||Aged, Aged, 80 and over, Aging, Alzheimer Disease, Cerebral Cortex, Executive Function, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Mild Cognitive Impairment, Neuropsychological Tests, Parietal Lobe, Saccades, Severity of Illness Index|
OBJECTIVE: The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions.
METHODS: We recorded eye movements in 182 subjects (NE: 118; MCI: 36; AD: 28) during an AS task. We also performed neuropsychological measures of executive function for comparison. Brain MRI scans were collected on most subjects, and cortical thickness was determined in 9 regions known to exhibit atrophy in AD dementia ("AD signature"). We investigated the relationships between AS and neuropsychological performance, as well as possible correlations between AS performance and cortical thickness.
RESULTS: AS performance in MCI resembled that in NE; subjects with AD were impaired relative to both MCI and NE. In all subjects, AS performance correlated with neuropsychological measures of executive function, even after controlling for disease severity. In the subjects with MCI but not in NE, cortical thickness in frontoparietal AD signature regions correlated with AS performance.
CONCLUSIONS: The AS task is a useful measure of executive function across the AD spectrum. In MCI, AS performance may reflect disease burden within cortical brain regions involved in oculomotor control; however, AS impairments in NE may have etiologies other than incipient AD.
|PubMed Central ID||PMC3795604|
|Grant List||P01 AG019724 / AG / NIA NIH HHS / United States |
P01AG019724 / AG / NIA NIH HHS / United States
P50 AG1657303 / AG / NIA NIH HHS / United States
P50-AG005134 / AG / NIA NIH HHS / United States
P50AG023501 / AG / NIA NIH HHS / United States
R01 AG031278 / AG / NIA NIH HHS / United States
R01 AG038791 / AG / NIA NIH HHS / United States
R01-AG030311 / AG / NIA NIH HHS / United States
R01AG031278 / AG / NIA NIH HHS / United States
R01AG032289 / AG / NIA NIH HHS / United States
R01AG038791 / AG / NIA NIH HHS / United States
R21-MH097094 / MH / NIMH NIH HHS / United States
R21-NS077059 / NS / NINDS NIH HHS / United States