|Title||Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an (11)C altropane positron emission tomography study.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Marquié, M, Locascio, JJ, Rentz, DM, J Becker, A, Hedden, T, Johnson, KA, Growdon, JH, Gomperts, SN|
|Journal||Alzheimers Res Ther|
INTRODUCTION: The biological basis of cognitive impairment in parkinsonian diseases is believed to be multifactorial. We investigated the contribution of dopamine deficiency to cognition in Parkinson disease (PD) and dementia with Lewy bodies (DLB) with dopamine transporter (DAT) imaging.
METHODS: We acquired (11)C altropane PET, magnetic resonance imaging and cognitive testing in 19 nondemented subjects with PD, 10 DLB and 17 healthy control subjects (HCS). We analyzed DAT concentration in putamen, caudate, anterior cingulate (AC), orbitofrontal and prefrontal regions, using the Standardized Uptake Volume Ratio with partial volume correction, and we related DAT concentration and global cortical thickness to neuropsychological performance.
RESULTS: DAT concentration in putamen and in caudate were similar in PD and DLB groups and significantly lower than in HCS. Reduced caudate DAT concentration was associated with worse Clinical Dementia Rating Scale-sum of boxes (CDR-SB) scores and visuospatial skills in DLB but not in PD or HCS groups. Adjusting for putamen DAT concentration, as a measure of severity of motor disease, caudate DAT concentration was lower in DLB than in PD. Higher AC DAT concentration was associated with lower putamen DAT concentration in DLB and with higher putamen DAT concentration in PD. Higher AC DAT concentration in DLB correlated with greater impairment in semantic memory and language.
CONCLUSIONS: Caudate and AC dopamine dysfunction contribute in opposing directions to cognitive impairment in DLB.
|Alternate Journal||Alzheimers Res Ther|
|PubMed Central ID||PMC4245149|
|Grant List||K01 AG040197 / AG / NIA NIH HHS / United States |
P50 AG005134 / AG / NIA NIH HHS / United States