Dr. Gomez-Isla Received her medical school training at the University Complutense, Madrid, Spain and completed her residency in neurology at Hospital Doce de Octubre, Madrid, Spain. She then completed a clinical and research fellowship in the Memory Disorders and Alzheimer's Research Laboratory of the Massachusetts General Hospital (MGH) in Boston. She has subserved as Chief of the Memory Disorders Unit at Clinica Universitaria of Navarre, Pamplona, Spain and Hospital Santa Cruz y San Pablo, Barcelona, Spain.
Dr. Gomez-Isla sees patients and conducts clinical research at the MGH and also performs basic research at the MassGeneral Institute for Neurodegenerative Disease (MGH MIND ).
I have specific interests in Alzheimer's disease and other dementias. I see patients with these disorders as part of clinical evaluation and care, as well as for research purposes.
There is a great need to understand the mechanisms that lead to neural system collapse and impaired cognition in Alzheimer's disease and related disorders, and to find better treatments potentially able to prevent or cure this illness. A large part of my research focuses on the development and characterization of transgenic mouse models of Alzheimer's disease and on testing novel therapeutic strategies. I also perform research on human brains from individuals who suffered Alzheimer's disease while alive, and cognitively-intact individuals across the age spectrum, searching for molecular mechanisms responsible for individual vulnerability/resilience to this type of dementia.
Gomez-Isla T, West HL, Rebeck GW, Harr SD, Growdon JH, Locascio JT, Perls TT, Lipsitz LA, Hyman BT. Clinical and Pathological Correlateds of Apolipoprotein E Epsilon 4 in Alzheimer's Disease. Ann Neurol 1996; 39: 62-70.
Gomez-Isla T, Price JL, McKeel DW, Morris JC, Growdon JH, Hyman BT. Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer's Disease. J Neurosci 1996; 16: 4491-4500.
Gomez-Isla T, Hollister R, West HL, Mui S, Growdon JH, Petersen RC, Parisi JE, Hyman BT. Neuronal Loss Correlates with But Exceeds Neurofibrillary Tangles in Alzheimer's Disease. Ann Neurol 1997; 41: 17-24.
Gomez-Isla T, Growdon WB, McNamara MJ, Nochlin D, Bird TD, Arango JC, Lopera F, Kosik K, Lantos PL, Cairns NJ, Hyman BT. The Impact of Different Presenilin 1 and Presenilin 2 Mutations on Amyloid Deposition, Neurofibrillary Changes and Neuronal Loss in the Familial Alzheimer's Disease Brain: Evidence for Other Phenotype-Modifying Factors. Brain 1999: 122: 1709-1719.
Ribe E, Perez M, Puig B, Gich I, Lim F, Cuadrado M, Sesma T, Catena S, Sanchez B, Nieto M, Gomez-Ramos P, Moran MA, Cabodevilla F, Samaranch L, Ortiz L, Perez A, Ferrer I, Avila J, Gomez-Isla T. Acceleated Amyloid Deposition, Neurofibrillary Degeneration and Neuronal Loss in Double Mutant APP/Tau Transgenic mice. Neurobiol Dis 2005; 20: 814-822.
Gomez-Isla T, Blesa R, Boada M, Clarimon J, Del Ser T, Domenech G, Ferro JM, Gomez-Anson B, Manubens JM, Martinez-Lage JM, Munoz D, Pena-Casanova J, Torres T, on behalf of the TRIMCI Study Group. A Randomized, Double-Blind, Placebo-Controlled Trial of Triflusal in Mild Cognitive Impairment: the TRIMCI Study. Alzheimer Dis Assoc Disord 2008; 22: 21-29.
Gomez-Isla T, Spires T, De Calignon A, Hyman BT. Neuropathology of Alzheimer's Dsiease. Handb Clin Neurol 2008; 89: 233-243.
Sereno L, Coma M, Rodriguez M, Sanchez-Ferrer P, Sanchez MB, Gich I, Agullo JM, Perez M, Avila J, Guardia-Laguarta C, Clarimon J, Lleo A, Gomez-Isla T. A Novel GSK-3 Beta Inhibitor Reduces Alzheimer's Pathology and Rescues Neuronal Loss In Vivo. Neurobiol Dis 2009; 35: 359-367.
Coma M, Sereno L, Da Rocha-Souto B, Scotton TC, Espana J, Sanchez MB, Rodriguez M, Agullo J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimon J, Lleo A, Bacskai BJ, Saura CA, Hyman BT, Gomez-Isla T. Triflusal Reduces Dense-Core Plaque load, Associated Axonal Alterations and Inflammatory Changes, and Rescues Cognition in a Transgenic Mouse Model of Alzheimer's disease. Neurobiol Dis 2010; 38: 482-491. [PMCID: 3707138].
Darocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Sereno L, Rodriguez M, Sanchez B, Hyman BT, Gomez-Isla T. Brain Oligomeric Beta-Amyloid But Not Total Amyloid Plaque Burden Correlates with Neuronal Loss and Astrocyte Inflammatory Response in Amyloid Precursor Protein/tau Transgenic Mice. J Neuropathol Exp Neurol 2011; 70: 360-376. [PMCID: 3725771].
More publications may be found at www.ncbi.nlm.nih.gov/