A Preseilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of Gamma-Secretase Activity

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Heling EA, Xia W, Shen J and Kelleher RJ 3rd (2010).  A preseilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem; 285:  22350-22359. PMCID:  2903357.