Olivia I. Okereke, MD, MS

Title: Neuropsychiatrist, Behavioral Neurology Clinic, Brigham and Women's Hospital & Assistant Professor of Epidemiology, Harvard School of Public Health & Assistant Professor of Psychiatry, Harvard Medical School
Telephone: (617) 726-5571
Biography:

Dr. Okereke provides part-time patient care as a neuropsychiatrist at the Behavioral Neurology Clinic of the Brigham and Women's Hospital, where she has an appointment in the Department of Psychiatry.

For more information on Dr. Okereke, please visit www.channing.harvard.edu/okereke.htm

Interests:

From 2007-2008, Dr. Okereke conducted a pilot grant from the Harvard NeuroDiscovery Center (www.neurodiscovery.harvard.edu) for the development of a streamlined instrument for the identification of decline along the mild end of the spectrum of cognitive impairment in older persons - a "pre-clinical" phase likely most amendable to prevention or early intervention in dementia. The project involved the selection of high-sensitivity items for the detection of mild cognitive change and the development of a brief, structured questionnaire that is utilized among research participants of the Massachusetts ADRC.

 

Apart from clinical activities at the Massachusetts ADRC and the above-mentioned research project, Dr. Okereke is also the Principal Investigator of a K08 (Career Development Award) from the National Institute on Aging (www.nia.nih.gov). This grant focuses on the relation of dietary factors, novel diet-related biomarkers and prospective cognitive function in a cohort of over six-thousand older women.  In addition, Dr. Okereke is involved in work on plasma amyloid-beta assays -- analyzing their performance characteristics and association with cognitive outcomes.

Publications:

van Dyck, CH, Gelernter J, MacAvoy MG, Avery RA, Criden M, Okereke O, Varma P, Seibyl JP, Hoffer PB. Absence of an Apolipoprotein E Epsilon4 Allele is Associated with Increased Parietal Regional Cerebral Blood Flow Asymmetry in Alzheimer's Disease. Arch Neurol 1998; 55:  1460-1466.

 

Okereke O, Hankinson SE, Hu FB, Grodstein F. Plasma C Peptide Level and Cognitive Function Among Older Women Without Diabetes Mellitus. Arch Intern Med 2005; 165:  1651-1656. [PMCID:  2396343].

 

Okereke OI, Folsom DP. Medical Comorbidity in Geriatric Psychiatry. Am J Geriatr Psychiatry 2005; 13:  177-179.

 

Okereke I, Kang JH, Gaziano JM, Ma J, Stampfer MJ, Grodstein F. Plasma C-Peptide and Cognitive Performance in Older Men Without Diabetes. Am J Geriatr Psychiatry 2006; 14:  1041-1050.

 

Okereke I, Kang JH, Ma J, Gaziano JM, Grodstein F. Midlife Plasma Insulin-Like Growth Factor I and Cognitive Function in Older Men. J Clin Endocrinol Metab 2006; 91:  4306-4312.

 

Okereke O, Kang JH, Ma J, Hankinson SE, Pollak MN, Grodstein F. Plasma IGF-I Levels and Cognitive Performance in Older Women.  Neurobiol Aging 2007; 28:  135-142.

 

Okereke OI, Faison WE. Ethnicity and Geriatric Psychiatry. Am J Geriatr Psychiatry. 2008;  16:  945-947.

 

Okereke OI, Kang JH, Cook NR, Gaziano JM, Manson JE, Buring JE, Grodstein F. Type 2 Diabetes and Cognitive Decline in Two Large Cohorts of Community-Dwelling Older Adults. J Am Geriatr Soc 2008; 56:  1028-1036.

 

Okereke OI, Pollak MN, Hu FB, Hankinson SE, Selkoe DJ, Grodstein F. Plasma C-Peptide Levels and Rates of Cognitive Decline in Older, Community-Dwelling Women Without Diabetes.  Psychoneuroendocrinology 2008; 33:  455-461. [PMCID:  2396343].

 

van Oijen M, Okereke OI, Kang JH, Pollak MN, Hu FB, Hankinson SE, Grodstein F. Fasting Insulin Levels and Cognitive Decline in Older Women Without Diabetes. Neuroepidemiology 2008; 30:  174-179. [PMCID:  2821443].

 

Devore EE, Stampfer MJ, Breteler MM, Rosner B, Hee KJ, Okereke O, Hu FB, Grodstein F. Dietary Fat Intake and Cognitive Decline in Women with Type 2 Diabetes. Diabetes Care 2009; 32:  635-640. [PMCID:  2660474].

 

Okereke OI, Selkoe DJ, Pollak MN, Stampfer MJ, Hu FB, Hankinson SE, Grodstein F. A Profile of Impaired Insulin Degradation in Relation to Late-Life Cognitive Decline:  A Preliminary Investigation.  Int J Geriatr Psychiatry 2009; 24:  177-182. [PMCID:  2631087].

 

Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance Characteristics of Plasma Amyloid Beta 40 and 42 Assays. J Alz Dis 2009; 16:  277-285. [PMCID:  2737811].

 

Okereke OI, Xia W, Selkoe DJ, Grodstein F. Ten-Year Change in Plasma Amyloid Beta Levels and Late-Life Cognitive Decline. Arch Neurol 2009; 66:  1247-1253. [PMCID:  2761951].

 

More publications may be found at www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed