Our fond or fearful memories - that first kiss or a bump in the night - leave memory traces that we may conjure up in the remembrance of things past, complete with time, place and all the sensations of the experiences. Neuroscience call these traces memory engrams.
2012 Alzheimer's Disease Facts and Figures provides a statistical resource for U.S. data related to Alzheimer's dsiease, the most common type of dementia, as well as other dementias. Background and context for interpretation of the data are contained in the Overview. This information includes definitions of the types of dementia and a summary of current knowledge about Alzheimer's disease.
Two independent laboratories -- one at Columbia University; the other, at Harvard Medical School -- have devised a clever set of experiments to prove that the pathology that leads to tangle formation in Alzheimer disease (AD) spreads across the brain from neuron to neuron rather than selectively hitting vulnerable regions at different time points over the course of the disease.
The finding answers a pivotal question as to how AD progresses, and could open the door to novel treatments that could stop the disease from spreading and damaging key cognitive circuits.
Repression of certain gene activity in the brain appears to be an early event affecting people with Alzheimer's disease, a new study found. In mouse models of Alzheimer's disease, this blockage and its effet on memory were treatable.
Alzheimer's disease is the most common cause of dementia in older adults. It affects as many as 5.1 million Americans. A hallmark of the disease is the accumulation of a toxic protein fragment called beta-amyloid in brain nerve cells (neurons). Preventing the cognitive problems that result has been a major medical challenge.
More and more retired people are heading back to the nearest classroom - as students and, in some cases, teachers - and they are finding out that school can be lovelier the second time around. Some may be thinking of second careers, but most just want to keep their minds stimulated, learn something new or catch up with a subject they were always curious about but never had time for.
The association of the inhaled anesthetic isoflurane with Alzheimer's-disease-like changes in mammalian brains may be caused by the drug's effects on mitochondria, the structures in which most cellular energey is produced.
Alzheimer's disease is an age-related brain disorder that gradually destroys a person's ability to remember, think, learn, and carry out even the simplest of tasks. Alzheimer's is a type of dementia, a broad term for diseases and conditions that damage brain cells and, over time, impair brain function. Alzheimer's is associated with the breakdown of connections between brain cells, or neurons, and their eventual death.
Airborne pollution can have serious consequences for the brain and the heart even at typical levels of exposure, according to the results of two studies published in the Feb 13 issue of Archives of Internal Medicine.
In one analysis, researchers led by Gregory Wellenius, ScD, of Brown University in Providence, R.I., found that short-term exposure to fine particulate matter - even at levels allowed by the EPA - can increase the risk of ischemic stroke.
The Obama administration plans to spend an additional $156 million over the next two years to help find an effective treatment for Alzheimer's, a fatal brain-wasting disease that affects more than 5 million Americans.
The White House said on Tuesday it will spend an extra $50 million this year, and it will seek an extra $80 million in fiscal 2013 to bolster Alzheimer's research. Obama also plans to spend an additional $26 million in programs to support people who care for Alzheimer's patients.
Alzheimer's disease seems to spread like an infection from brain cell to brain cell, two new studies in mice have found. But instead of viruses or bacteria, what is being spread is a distorted protein known as tau.
The surprising finding answers a longstanding question and has immediate implications for developing treatments, researchers said. And they suspect that other degenerative brain diseases like Parkinson's may spread in a similar way.