Marta Marquie-Sayagues, MD, PhD

Title: Clinical Fellow in Neurology, Harvard Medical School
Telephone: (617) 643-0870

Dr. Marquie-Sayagues received her Medical Degree at the University of Barcelona Medical School in Spain (1997-2003) and compled the Residency Training Program in Neurology at the Hospital de Sant Pau in Barcelona (2004-2008). She is currently enrolled in a PhD Program in Internal Medicine at the Autonomous University of Barcelona.


Dr. Marquie-Sayagues received her postgraduate clinical training at the Memory Disorder Unit at Hospital Sant Pau (2008-2010), where she specialized in the diagnosis and management of dementia and other cognitive disorders. In 2010 Dr. Marquie-Sayagues joined the the Massachusetts General Hospital as a Research fellow. She conducted her research at the Movement Disorders Unit and at the MassGeneral Institute for NeuroDegenerative Disease. In July 2015 Dr. Marquie-Sayagues joined the Memory Disorders Unit at the Massachusetts General Hospital as a Clinical Fellow, where she combines clinical duties with basic and translational research.


The central theme of Dr. Marquie-Sayagues’ research is the postmortem validation of novel PET compounds for the diagnosis of neurodegenerative disorders. Specifically, Dr. Marquie-Sayagues analyzes Pittsburgh Compound B, AV-1451 (T807) and Altropane in Alzheimer´s disease, dementia with Lewy body and other neurodegenerative disorders both with in vivo PET imaging and postmortem human brain tissue from autopsies.


Martínez-Hernández E, Martínez-Ramírez S, Delgado-Mederos R, Alcolea D, Marquié M, Marín R, De Juan M, Martí-Vilalta JL, Martí-Fàbregas J. Remote Cerebral Hematomas in Patients Treated with Intravenous rt-PA. J Neurol 2010; 257: 1062-1066.


Camacho V, Marquié M, Lleó A, Alvés L, Artigas C, Flotats A, Duch J, Blesa R, Gómez-Isla T, Carrió I, Estorch M. Cardiac Sympathetic Impairment Parallels Nigrostriatal Degeneration in Probable Dementia with Lewy Bodies. Q J Nucl Med Mol Imaging 2011; 55: 476-483.


Marquie M, Camacho V, Lleo A, Alves L, Artigas C, Flotats A, Duch J, Blesa R, Gomez-Isla T, Carrio I, Estorch M. Cardiac Sympathetic Impairment Parallels Nigrostriatal Degeneration in Probable Dementia in Lewy Bodies. Q J Nucl Med Mol Imaging 2011; 55: 476-483.


Seto-Salvia N, Clarimon J, Pagonabarraga J, Pascual-Sedano B, Campolongo A, Combarros O, Mateo JI, Regana D, Martinez-Corral M, Marquie M, Alcolea D, Suarez-Calvet M, Molina-Porcel L, Dols O, Gomez-Isla T, Blesa R, Lleo A, Kulisevksky J. Dementia Risk in Parkinson's Disease:  Disentangling the Role of MAPT Haplotypes. Arch Neurol 2011; 68:  359-364.


Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH. Brain Amyloid and Cognition in Lewy Body Diseases. Mov Disord 2012; 27: 965-973. [PMCID:  3725259].


Sala I, Marquie M, Sala I, Sanchez-Saudinos MB, Sanchez-Valle R, Alcolea D, Gomez-Isla T, Blesa R, Lleo A. Rapidly Progressive Dementia:  Experience in a Tertiary Care Medical Center. Alzheimer Dis Assoc Disord 2012; 26:  267-371.


Camacho V, Estorch M, Marquié M, Domènech A, Flotats A, Fernández A, Duch J, Geraldo LL, Deportos J, Artigas C, Lleó A, Carrió I. Utility of Early Imaging of Myocardial Innervation Scintigraphy in the Diagnosis of Lewy Body Dementia. Rev Esp Med Nucl Imagen Mol 2013; 32: 77-80.


Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH. Amyloid is Linked to Cognitive Decline in Patients with Parkinson Disease Without Dementia. Neurology 2013;80:  85-91. [PMCID:  3589197].


Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, Ikonomovic MD, López OL, Klunk W, Hyman BT, Gómez-Isla T. Dissecting Phenotypic Traits Linked to Human Resilience to Alzheimer's Pathology. Brain 2013; 136: 2510-2526. [PMCID:  3722351].


Marquie M, Locascio JJ, Rentz DM, Becker JA, Hedden T, Johnson KA, Growdon JH, Gomperts SN. Striatal and Extrastriatal Dopamine Transporter Levels Relate to Cognition in Lewy Body Diseases: An (11)C Altropane Positron Emission Tomography Study. Alzheimers Res Ther 2014; 6: 52.doi: 10.1186/s13195-014-0052-7. [PMCID:  4245149].


Marquie M, Normandin MD, Vanderburg CR, Costantino I, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gomez-Isla T. Validating Novel Tau PET Tracer [F-18]-AV-1451 (T807) On Postmortem Brain Dissue. Ann Neurol 2015; Sep 7. [PMCID Journal - In Process].


More publications may be found at