Joseph J. Locascio, PhD

Title: Biostatistician, Massachusetts Alzheimer's Disease Research Center & Assistant Professor of Neurology, Harvard Medical School
Telephone: (617) 724-7192

Dr. Locascio has had a research appointment as a senior biostatistician for the Alzheimer's Disease Research Center and Memory/Movement Disroders Units, Department of Neurology at Massachusetts General Hospital since 1992, and is an Assistant Professor of Neurology at Harvard Medical School. He had a dual appointment as research statistician in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT) from 1992 to 2009 where he taught formal and finromal data analysis courses.  He is a Consulting Statistician for the Harvard Catalyst Bio-Statistical Consulting Group of Harvard Medical School, and is a member of the Statistical Advisory Board for the journal PLOS One (Public Library of Science).  He has also taught statistics at Northwestern University (1982) and worked as a statistician in psychiatric research at the University of Chicago (1983-1985) and Bellevue Hospital/New York University Medical Center (1989-1991).


Dr. Locascio has 90 publications in prestigious medical, scientific, and scholarly journals, magazines, and books.


Data analysis methods - longitudinal methods, structural equation models, time series, and other biostatistical and behavioral science statistical methods. Research in neurodegenerative disorders.


Updates coming soon........


Atri A, Shaughnessy LW, Locascio JJ, Growdon JH. Long-Term Course and Effectiveness of Combination Therapy in Alzheimer Disease. Alzheimer Dis Assoc Disord 2008; 22:  209-222. [PMCID:  2718545].


Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz L, Hyman BT. Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects without Alzheimer's Disease.  J Neuropathol Exp Neurol 2008; 67:  1-8. [PMCID:  2734185].


Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging Amyloid Deposition in Lewy Body Diseases. Neurology 2008; 71:  903-310. [PMCID:  2637553].


Locascio JL, Fukumoto H, Yap, L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC. Plasma Amyloid Beta Protein and C-Reactive Protein in Relation to Rate of Progression of Alzheimer Disease. Arch Neurol 2008; 65:  776-785. [PMCID:  2662621].


Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, Schlossmacher MG. Direct Quantification of CSF Alpha-Synuclein by ELISA and First Cross-Sectional Study in Patients with Neurodegeneration.  Exp Neurol 2008; 213:  315-325.


Farabaugh A, Locascio JJ, Yap L, Weintraub D, McDonald WM, Agoston M, Alpert J, Growdon J, Fava M. Depressive Symptom Patterns in Parkinson's Disease. Psychosomatics 2009; 50:  448-454.


Wonderlick JS, Ziegler DA, Hosseini-Varnamkhasti P, Locascio JJ, Bakkour A, Van der Kouwe A, Triantafyllou C,Corkin S, Dickerson BC.  Reliability of MRI-Derived Cortical and Subcortical Morphometric Measures:  Effects of Pulse Sequence, Voxel Geometry, and Parallel Imaging.  Neuroimage 2009; 44:  1324-1333.  [PMCID:  2739882].


Farabaugh A, Locascio JJ, Yap L, Growdon J, Fava M, Crawford C, Matthews J, McCutchen J, Buchin J, Petersen T, Pava J, Alpert JE. Cognitive Behavior Therapy for Patients with Parkinson’s Disease and Comorbid Major Depressive Disorder. Psychosomatics 2010; 51:  124-129.
More publications may be found at www.ncbi.nlm.nih/gov/sites/entrez?db=pubmed