Joseph J. Locascio, PhD

Title: Biostatistician, Massachusetts Alzheimer's Disease Research Center & Assistant Professor of Neurology, Harvard Medical School
Telephone: (617) 724-7192

Dr. Locascio has had a research appointment as a senior biostatistician for the Alzheimer's Disease Research Center and Memory/Movement Disorders Units, Department of Neurology at Massachusetts General Hospital since 1992, and is an Assistant Professor of Neurology at Harvard Medical School. He had a dual appointment as research statistician in the Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology (MIT) from 1992 to 2009 where he taught formal and informal data analysis courses.  He is a Consulting Statistician for the Harvard Catalyst Bio-Statistical Consulting Group of Harvard Medical School, and is a member of the Statistical Advisory Board for the journal PLOS One (Public Library of Science).  He has also taught statistics at Northwestern University (1982) and worked as a statistician in psychiatric research at the University of Chicago (1983-1985) and Bellevue Hospital/New York University Medical Center (1989-1991).


Dr. Locascio has 90 publications in prestigious medical, scientific, and scholarly journals, magazines, and books.


Data analysis methods - longitudinal methods, structural equation models, time series, and other biostatistical and behavioral science statistical methods. Research in neurodegenerative disorders.


Locascio, J.  A Statistical Suggestion (Letters). Scientific American 2011; 305: 8-10.       


Locascio JJ, Atri A.  An Overview of Longitudinal Data Analysis Methods for Neurological Research. Dement Geriatr Cog Dis 2011; 1:  330-357. [PMCID: PMC3243635].     


Gomperts SN, Locascio J, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH.  Amyloid is Linked to Cognitive Decline in Non-Demented Parkinson Disease Patients.  Neurology 2013; 80:  85-91. [PMC:  3589197].  


Herskovits ZA, Locascio JJ, Peskind ER, Li G, Hyman BT.  A Luminex Assay Detects Amyloid β Oligomers in Alzheimer’s Disease Cerebrospinal Fluid. PLoS One 2013; 8: e67898. [PMCID:  3699502]. 


Ding H, Kaltra D, Lockhart K, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills A-M, Mollenhauer B, Flaherty AW, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schlossmacher M, Hyman BT, Sudarsky LR, Growdon J  Scherzer CR. Unrecognized Vitamin D Deficiency is Common in Parkinson’s: Harvard Biomarker Study. Neurology 2013; 81: 1-7. [PMCID:  3888173].


Locascio JJ.   The Reality of Racism Based on the Illusion of Race. The American Psychologist 2014; 69:  3510-311.


Marquie M, Locascio JJ, Rentz DR, Becker JA, Hedden T, Johnson KA, Growdon JH, Gomperts SN.  Striatal and Extrastriatal Dopamine Transporter Levels Relate to Cognition in Lewy body Diseases:  An 11C Altropane Positron Emission Tomography Study.  Alzheimer's Res Ther 2014; 6: 52. [PMCID:  4245149].


Marshall GA, Lorius N, Locascio JJ, Hyman BT, Rentz DM, Johnson KA, Sperling RA. Regional Cortical Thinning and Cerebrospinal Biomarkers Predict Worsening Daily Functioning Across the Alzheimer Disease Spectrum.  J Alzheimer’s dis 2014; 41:  719-728. [PMCID:  4111766]. 


Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA.   Cognitive Activity Relates to Cognitive Performance, But Not to Alzheimer’s Disease Biomarkers. Neurology 2015. [PMC Journal - In Process].

Locascio JJ.  Psychology and Statistics: Readers Respond to the BASP Ban on p-Values.  Significance Magazine 2015:  35-36.  


Locascio JJ, Eberly S, Liao Z, Liu G, Hyman BT, Growdon J, Schlossmacher M, Scherzer CR., et al.  Association Between α-Synuclein Blood Transcripts and Early, Neuroimaging-Supported Parkinson’s. Brain 2015. [PMC Journal - In Process].   


Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Viswanathan A, Marshall GA, Alzheimer’s Disease Neuroimaging Initiative. Vascular Disease and Risk Factors are Associated with Cognitive Decline in the Alzheimer’s Disease Spectrum. Alzheimer Dis Assoc Disord 2015; 29:18-25. [PMCID:  4366000].       


More publications may be found at