Gad A. Marshall, MD

Title: Associate Medical Director of Clinical Trials, Center for Alzheimer's Research and Treatment, Brigham and Women's Hospital & Assistant Professor of Neurology, Harvard Medical School
Telephone: (617) 732-8085
Biography:

During my medical education at the Boston University School of Medicine, medical internship/neurology residency at the University of Pittsburgh and dementia fellowship at the University of California, Los Angeles, I developed both my clinical and research interests in Alzheimer's disease.  Along the way, I have collaborated with multiple investigators who encouraged and nurtured my drive to better understand this devastating disorder and find effective treatments.

 

I currently work as a behavioral neurologist at the Brigham and Women's Hospital and the Massachusetts General Hospital, focusing on clinical trials and neuroimaging biomarkers in Alzheimer's disease and its precursor stages.

Interests:

I have a long-standing interest in clinical-pathologic and imaging correlates in Alzheimer's disease.  Most recently, I have been using PET imaging to assess the relationship between apathy, executive function and instrumental activities of daily living, in vivo amyloid deposition (PiB PET) and synaptic integrity (FDG PET) in mild cognitive impairment and mild Alzheimer's disease.

 

My other main research interest and involvement is in clinical trials for the treatment of Alzheimer's disease.

Publications:

Marshall GA, Kaufer DI, Lopez OL, Rao GR, Hamilton RL, DeKosky ST. Right Proscubiculum Amyloid Plaque Density Correlates with Anosognosia in Alzheimer's Disease.  J Neurol Neurosurg Psychiatry 2004; 75:  1396-1400. [PMCID:  1738763].

 

Marshall GA, Hendrickson R, Kaufer DI, Ivanco LS, Bohnen NI. Cognitive Correlates of Brain MRI Subcortical Signal Hyperintensities in Non-Demented Elderly. Int J Geriatr Psychiatry 2006; 21:  32-35.

 

Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL. Neuropathologic Correlates of Activities of Daily Living in Alzheimer's Disease. Alzheimer Dis Assoc Disord 2006; 20:  56-59.

 

Marshall GA, Fairbanks LA, Tekin S, Vinters HV, Cummings JL. Neuropathologic Correlates of Apathy in Alzheimer's Disease. Dement Geriatr Cogn Disord 2006; 21:  144-147. [PMC Journal - In Process].

 

Marshall GA, Shchelchkov E, Kaufer DI, Ivanco LS, Bohnen NI. White Matter Hyperintensities and Cortical Acetylcholinesterase Activity in Parkinsonian Dementia. Act Neurol Scand 2006; 113:  87-91.

 

Marshall GA, Monserratt L, Harwood D, Mandelkern M, Cummings JL, Sultzer DL. Positron Emission Tomography Metabolic Correlates of Apathy in Alzheimer's Disease. Arch Neurol 2007; 64:  1015-1020.

 

Sperling RA, Laviolette PS, O’Keefe K, O’Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid Deposition is associated with Impaired Default Network Function in Older Persons Without Dementia. Neuron 2009; 63:  178-188. [PMCID:  2738994].

  

Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, Fischl B, Greve D, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA, Johnson KA. Amyloid-Beta Associated Cortical Thinning in Clinically Normal Elderly. Ann Neurol 2011; 69:  1032-1042. [PMCID:  3117980].

 

Marshall GA, Rentz DM, Frey MT, Locascio JJ, Johnson KA, Sperling RA, Alzheimer’s Disease Neuroimaging Initiative. Executive Function and Instrumental Activities of Daily Living in Mild Cognitive Impairment and Alzheimer’s Disease. Alzheimers Dementia 2011; 7:  300-308. [PMCID:  3096844].

 

Marshall GA, Olson LE, Frey MT, Maye J, Becker JA, Rentz DM, Sperling RA, Johnson KA, Alzheimer’s Disease Neuroimaging Initiative. Instrumental Activities of Daily Living Impairment is associated with Increased Amyloid Burden. Dement Geriatr Cogn Disord. In Press. [PMC Journal - In Process]. 

 

More publications may be accessed at www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed