E. Tessa Hedley-Whyte, MBBS, MD

Title: Professor of Pathology, Harvard Medical School
Telephone: (617) 726-5154
Biography:

I have spent many years studying various aspects of neurodegenerative diseases in collaboration with other members of the Massachusetts Alzheimer's Disease Research Center (ADRC) and I continue to mentor trainees and colleagues in the diagnosis and classification of these diseases. In this role, I am responsible for the diagnosis of approximately half of the postmortem cases from the ADRC.

Interests:

Neuropathology; autopsy pathology; frozen section pathology

Publications:

Newell KL, Hyman BT, Growdon JH, Hedley-Whyte ET. Application of the National Institute of Aging (NIA)-Reagan Institute Criteria for the Neuropathological Diagnosis of Alzheimer's Disease.  J Neuropathol Exper Neurol 1999; 58:  1147-1155.

 

Silver MH, Newell KKL, Brady C, Hedley-Whtye ET, Perls TT. Distinguishgin Between Neurodegenerative Disease and Disease-Free Aging:  Correlating Neuropsychological Evaluations and Neuropathological Studies in Centenarians. Psychosom Med 2002; 64:  493-501.

 

Ingelsson M, Fukumoto H, Newell K, Growdon JH, Hedley-Whyte ET, Frosch MP, Albert MS, Hyman BT, Irizarry MC.  Early Abeta Accumulation and Progressive Synaptic Loss, Gliosis and Neurofibrillary Tangle Formation in AD Brain. Neurology 2004; 62:  925-931.

 

Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon JH, McLean P, Hyman BT. Clinical and Biochemical Correlates of Insoluble Alpha Synuclein in Dementia with Lewy Bodies. Acta Neuropathol 2006; 111:  101-108.

 

Hedley-Whyte ET. On Being a Pathologist:  How Does One Plan a Career or Does One? Hum Pathol 2008; 39:  1269-1274.

 

Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of Neuronal Number Despite Age-Related Cortical Brain Atrophy in Elderly Subjects without Alzheimer's Disease. J Neuropathol Exp Neurol 2007; 67:  1205-121. [PMCID:  2734185].

 

McKee AC, Cantu RC, Nowinski CJ, Hedley-Whyte ET, Gavett BE, Budson AE, Santini VE, Lee H-Y, Kubilus CA, Stern RA.  Chronic Traumatic Encephalopathy in Athletes:  Progressive Tauopathy After Repetitive Head Injury. J Neuropathol Exp Neurol 2009; 68:  709-735. [PMCID:  2945234]. 

 

McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perls D, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee H-Y, Kubilus CA, Danshevar D, Wulff M, Budson AE.  TDP-43 Proteinopathy and Motor Neuron Disease in Chronic Traumatic Encephalopathy. J Neuropath Exp Neurol 2010; 69:  918-929. [PMCID:  2951281].

 

Lain AH, Lieberman Ap, Pfannl R, Hedley-Whyte ET. Nodular Bilateral Amygdala Degeneration in Demented Individuals. Acta Neuropathol 2010; 120:  683-688. [PMCID:  3057016].

 

More publications may be found at www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed