Active clinical trial

WHAT IS THE REVEAL STUDY?

Many people with mild memory concerns wonder whether they will develop Alzheimer's disease (AD).

The REVEAL study is a multi-center, NIH-funded research project based at Brigham and Women's Hospital.

The goal of REVEAL is to use genetic information to help predict whether someone with mild memory problems will develop AD.

WHO IS ELIGIBLE TO PARTICIPATE?

You may participate if you:

* Speak and read English

* Have been given a diagnosis of Mild Cognitive Impairment (MCI)

* Have a close friend or family member to be a study partner

More information is attached.

We are seeking healthy adults, aged 18 or older, to participate in a research study. The goal of the study is to examine olfactory function (or the sense of smell) in healthy individuals and in individuals with asymptomatic prodromal Alzheimer's disease, clinical Alzheimer's disease, Mild Cognitive Impairment, Dementia with Lewy Bodies, and Frontotemporal Dementia.

If you qualify, you will be asked to take a test that measures your ability to identify a group of everyday odors. You will also be asked to undergo an MRI brain scan. While we take pictures of your brain, we will present you with odors and ask you to let you know when you can smell them.

We are seeking healthy adults, aged 18 or older, to participate in a research study. The goal of the study is to examine olfactory function (or the sense of smell) in healthy individuals and in preclinical and clinical subjects with Alzheimer's Disease, Dementia with Lewy Bodies, or Frontotemporal Dementias.

If you qualify, you will be asked to undergo tests that measure your ability to discriminate, identify, remember, and evaluate a group of everyday odors. The study will take place at the Departments of Neurology or Psychiatry of the Massachusetts General Hospital (either on the Charlestown Navy Yard or the main campus of the hospital). It will take approximately one hour to complete the tests.

You will be asked to do this once a year. You will not be paid for participating in the study.

We are in need of volunteers to participate in a memory and high blood pressure study at Massachusetts General Hospital. We would greatly appreciate your help!

You may be eligible if you...

-Are age 60 or older

-Have high blood pressure or are taking blood pressure medication

-Have memory concerns

-Have someone close to you who can answer questions about your daily activities

This two year research study involves:

-Evaluation including memory tests each year

-Brain imaging at study entry and at 2 years

You will receive:

-$40 each clinic visit for you and your study partner

-$50 for MRI visits and $100 for PET imaging visits for you

Please contact the Gerontology Research Unit (Tel:  617-643-5200) if you are interested in participating.

Thank you!

We are seeking healthy adults, 65 to 90 years of age to participate in a research study. The purpose of the study is to develop ways for understanding brain changes affecting memory and thinking that occur with age.

Participants will be asked questions about their memory and thinking and must have a friend or relative who can answer 30 minutes of questions about your day-to-day activities.  If you qualify, you will be asked to have 8 brain scans at year 1 and 3, follow-up memory and thinking testing as well as blood draws annually for five years (at 12, 24, 36, 48 & 60 monhts) after the initial visit.

You may also participate in an optional study where you will have 2 lumbar punctures (spinal taps).

All evaluations will be free of cost and reimbursement for time and transporation is $1600.

We are seeking healthy adults, 55-90 years old for those with memory impairment or Alzheimer's disease and 65-90 years old for those without memory impairment, to participate in a research study. The goal of the study is to determine whether imaging of the brain (through MRI, PET and amyloid imaging scans) can help predict and monitor the onset and progression of Alzheimer's disease.

In addition to neuroimaging, the study will collect and test blood and cerebral spinal fluid to determine if biomarkers can predict and monitor the disease. Testing cerebral spinal fluid is the only way to obtain important brain information.

Participants will be asked questions about their memory and thinking and must have a friend or relative who can answer 30 minutes of questions about your day-to-day activities and accompany you to all clinic visits.

If you qualify, you will be asked to have 13 brain scans over the course of 54 months, follow-up memory and thinking testing as well as blood draws every 6 months after the initial visit for a period of 54 months. You will also be asked to have a lumbar puncture (spinal tap).

All evaluations will be free of cost and reimbursement for time and transportation will be up to $1750.

What is DIAN?

DIAN stands for the Dominantly Inherited Alzheimer’s Network.  This international network has been established by the National Institute on Aging of the National Institutes of Health (US) to bring together researchers who study genetic forms of Alzheimer’s disease (AD). 

The DIAN research volunteers are members of families in which AD is dominantly-inherited, meaning that about 50% of the individuals in each generation of a family develop AD, generally before age 60.  These rare forms of AD are caused by a mutation in one of 3 genes.  Each child of an affected parent has a 50% chance of inheriting the mutation.  If they do, they will develop the dementia of AD at about the same age as their parent.  Siblings who do not have the mutation have no greater risk of developing AD than someone without a family history of AD and will participate in DIAN as part of a comparison group for their mutation-carrying siblings.

Please see the attached study description for more information.

We are seeking healthy adults, 60 to 90 years of age to participate in a research study. The purpose of the study is to develop ways for understanding memory changes that occur with age. Participants will be asked questions about their memory and must have a friend or relative who can answer ten minutes of questions over the telephone about day-to-day activities.

If you qualify, you will be asked to have 3 brain scans and follow-up memory testing annually for five years after your first testing. All evaluations will be free of cost and reimbursement for time and transportation is $750 if you complete all visits. All information is kept completely confidential.

We are seeking healthy volunteers and individuals with Mild Cognitive Impairment (MCI) or Mild Alzheimer's Disease (AD) who are interested in taking part in a clinical research study to find out if functional MRI images of the brain can be used to diagnose and monitor the course and treatment of MCI and AD. Subjects must have a study partner and be willing to come to six to eight clinic visits over the course of two to three years.

At each of these visits, subjects will be asked to have blood drawn, undergo tests of memory and have an MRI scan of the brain. Each visit will last between four to five hours. Study participants will be reimbursed $50.00 for the completion of each scan visit and for parking.  All information is kept completely confidential.

ELIGIBILITY CRITERIA

Inclusion criteria:

1. Fifty-five to ninety years of age.

2. Healthy volunteer (MMSE 27-30) or patient with a diagnosis of MCI (MMSE 26-30) or Mild AD (MMSE 20-26).

Exclusion criteria:

1. Significant neurological disease other than Alzheimer's dsiease.

2. Clinically-significant and/or un-controlled medical condition.

3. History of alcohol abuse or dependence within the past two years.

4. Participation in another clinical research trial in which memory tests are being collected more than one time per year.