Active clinical trial

Use of [18F]MK-6240 Positron Emission Tomography to Evaluate Neurofibrillary Tangle Pathology in Alzheimer’s Disease, MCI, and Normal Elderly

Study Status: 
Active
Study Description: 

We will use PET and MRI imaging to study two different proteins in the brain, called amyloid and tau, to study their role in several brain disorders, including Alzheimer’s Disease and mild cognitive impairment. The study will take up to 1 month to complete and may take up to 5 visits. 

 

- Screening visit (including blood draw and other tests for eligibility)

- Cognitive testing

- MRI

- Amyloid PET

- Tau PET (including arterial blood sampling)

 

Study Population: Healthy volunteers, AD and MCI patients (ages 55-85)

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

A Phase 2 Multiple Dose, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of ABBV-8E12 in Subjects with Early Alzheimer’s Disease

Study Status: 
Active
Study Description: 

The study is designed to examine the safety and efficacy of a drug that targets the protein tau in the brains of people with Alzheimer’s disease. Research has shown that cognitive decline in patients with Alzheimer’s disease may relate to levels of abnormal tau protein in the brain.

 

More information is attached.

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

Assessment of Brain Insulin Resistance in Alzheimer's Disease with Insulin Clamp

Study Status: 
Active
Study Description: 

Are you:

□ between the ages of 55-85?
□ able to have an MRI?
□ interested in participating in research?

 

The MassGeneral Institute for Neurodegenerative Disease (MIND) is seeking both healthy individuals and individuals with Mild Cognitive Impairment (MCI) or Dementia due to Alzheimer’s Disease to participate in a research study.

 

More information is attached.

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator Tel:  617-643-5200

Tau Imaging in Parkinson Disease (PD) Dementia

Study Status: 
Active
Study Description: 

Coming soon!

Sub-Clinical Paroxysmal EEG Abnormalities in Alzheimer's Disease

Study Status: 
Active
Study Description: 

What is our study about?

We want to see if there are brainwave abnormalities in the brains of people with Alzheimer’s Disease and determine whether there is a distinct brainwave signature for Alzheimer’s Disease. This is a study where you will wear a portable EEG, play memory games on an iPad, and then wear the device home for 3 days!

 

Are you eligible to participate?

You may qualify if you are 50 to 90 years old, have amnestic mild cognitive impairment or Alzheimer’s Disease, and have no history of seizures or brain injury.

 

More information about the study is attached.

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

4-Repeat Tauopathy Neuroimaging Initiative - Cycle 2

Study Status: 
Active
Study Description: 

Coming soon!

Neural and Cognitive Changes Associated with Mental Training in Older Adults

Study Status: 
Active
Study Description: 

This study examines the effect of cognitive enhancement programs on age related changes in memory and attention.

 

ELIGIBLE?
We are seeking healthy, right-handed adults between the ages of 65-80. If eligible, you will receive 8 professional cognitive training sessions free of charge. You will also receive take-home exercises to supplement your training classes, and will be asked to complete these exercises daily for the duration of the 8-week program.

 

You will come in for 5 study visits: before the course, after the course, and at 6, 12, and 24 months after the start of the study. These study visits include surveys, cognitive tests, and a total of 3 fMRI scans. In addition to the cognitive training courses, participants will receive compensation up to $275 for completing all study visits.

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Study Status: 
Active
Study Description: 

Our Research. Your Story.

Research is happening at Massachusetts General Hospital (MGH) that is focused on learning about the cognitive abilities, personality, and other traits of people who have more than one blood relative affected with Frontotemporal Degeneration (FTD), Alzheimer’s disease, and related disorders.

 

You Can Contribute to the Cause

Diagnosis of FTD is often challenging and current treatment options are limited.  We hope that the scientific research we are conducting at MGH will change that for future generations.

 

We are seeking people or relatives of people who have been diagnosed with FTD, Progressive Supranuclear Palsy (PSP), Corticobasal Degeneration (CBD) or FTD with Amyotrophic Lateral Sclerosis (ALS), or have a relative with a mutation in the three most common genes associated with FTD (MAPT, PGRN/GRN, C9ORF72). By listening and learning about you and your family, we hope the knowledge gained from this work will help researchers and doctors to learn if there are certain cognitive or behavioral traits that can help predict the development of these disorders.

 

More information about the study is attached.

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)

Study Status: 
Active
Study Description: 

 

Our Research. Your Story.

Research is happening at Massachusetts General Hospital (MGH) that is focused on learning about the cognitive abilities, personality, and other traits of people who have more than one blood relative affected with Frontotemporal Degeneration (FTD), Alzheimer’s disease, and related disorders.

 

You Can Contribute to the Cause

Diagnosis of FTD is often challenging and current treatment options are limited.  We hope that the scientific research we are conducting at MGH will change that for future generations.

We are seeking people who are members of families with a known mutation in one of the three major FTLD related genes: MAPT, PGRN, and C9ORF72.  By listening and learning about you and your family, we hope the knowledge gained from this work will help researchers and doctors to learn if there are certain cognitive or behavioral traits that can help predict the development of these disorders.

 

More information about the study is attached!

Study Coordinator(s): 

Clinical Trials and Research Studies Coordinator

Tel:  617-643-5200

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