Annual Pilot

Development and Characterization of a Transgenic Mouse Model for Cerebral Amyloid Angiopathy

Project Year(s): 
1999 - 2000
Principal Investigator(s): 

Steven M. Greenberg, MD, PhD

Most Recent/Current Position(s): 

Director, Hemorrhagic Stroke Research Program, Massachusetts General Hospital & Professor (Neurology), Harvard Medical School

Functional Characterization of the Alpha-2-Macroglobulin Variant Linked to Late-Onset Alzheimer's Disease

Project Year(s): 
1999 - 2000
Principal Investigator(s): 

Aleister J. Saunders, PhD

Most Recent/Current Position(s): 

Director, Drexel University RNAi Resource Center & Interim Associate Department Head & Associate Professor (Biology, Biochemistry & Molecular Biology, Neurobiology & Anatomy), Drexel University

The Role of DNA Damage in Early Stages of Alzheimer-Related Neuropathology and in Experimental Models of Cell Injury

Project Year(s): 
1999 - 2000
Principal Investigator(s): 

Emil Adamec, MD, PhD

Most Recent/Current Position(s): 

Professor (Neuroscience and Pharmacology), Lake Erie College of Osteopathic Medicine, Bradenton, FL

Beta-Amyloid Induced Neuronal Death: Mechanisms and Intervention Strategies

Project Year(s): 
1998 - 1999
Principal Investigator(s): 

Mina Yaar, MD

Most Recent/Current Position(s): 

Interim Chair & Professor (Dermatology), Boston University

The Role of the A2a Adenosine Receptor in Learning and Memory in Young and Aging Mice

Project Year(s): 
1998 - 1999
Principal Investigator(s): 

Michael A. Schwarzschild, MD, PhD

Most Recent/Current Position(s): 

Associate Professor (Neurology), Harvard Medical School

Perfusion of Entorhinal Cortex in Alzheimer's Disease

Project Year(s): 
1998 - 1999
Principal Investigator(s): 

Leena M. Hamberg, PhD, ScD

Most Recent/Current Position(s): 

Director of Clinical Trials, Massachusetts General Hospital Department of Neuroradiology

High Resolution Magic Angle Spinning Protron MR Spectroscopy

Project Year(s): 
1998 - 1999
Principal Investigator(s): 

Leo Ling Cheng, PhD

Most Recent/Current Position(s): 

Assistant Professor (Radiology & Pathology), Harvard Medical School

The APP and Ferritin Genes are Regulated at the Translational Level by Iron and Interleukin-1

Project Year(s): 
1997 - 1998
Principal Investigator(s): 

Jack T. Rogers, PhD

Most Recent/Current Position(s): 

Associate Professor (Psychiatry & Neuroscience), Harvard Medical School

Cellular Uptake of ApoE Containing Lipoproteins in Primary Neuronal and Astrocytic Cells

Project Year(s): 
1997 - 1998
Principal Investigator(s): 

G. William Rebeck, PhD

Most Recent/Current Position(s): 

Associate Professor (Neuroscience), Georgetown University

Temporal Characterization of Amyloid-Associated Proteins During Alzheimer's Disease Plaque Amyloid Development in Three Model Systems

Project Year(s): 
1997 - 1998
Principal Investigator(s): 

Cynthia A. Lemere, PhD

Most Recent/Current Position(s): 

Associate Professor (Neurology), Harvard Medical School

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