Annual Pilot

High-Resolution MRI of Brain Function and Structure in Aging and Mild Cognitive Impairment: A Pilot Study

Project Year(s): 
2006 - 2007
Principal Investigator(s): 

Bradford C. Dickerson, MD

Most Recent/Current Position(s): 

Co-Director, Neuroimaging Group, Massachusetts ADRC/Massachusetts General Hospital Gerontology Research Unit & Director, Massachusetts General Hospital Frontotemporal Disorders Unit & Associate Professor (Neurology), Harvard Medical School

Signaling Mechanisms Underlying A-Beta Mediated Inhibition of Synaptic Plasticity

Project Year(s): 
2005 - 2006
Principal Investigator(s): 

T. Matthew Townsend, PhD

Most Recent/Current Position(s): 

Senior Research Biologist, Merck & Co, Inc.

Antibody Independent Mucosal Vaccination in Alzheimer's Disease Mice

Project Year(s): 
2005 - 2006
Principal Investigator(s): 

Dan Frenkel, PhD

Most Recent/Current Position(s): 

Lecturer (Neurobiology), Tel Aviv University, Israel

FAD APP Mutations and Molecular Neuropathology

Project Year(s): 
2005 - 2006
Principal Investigator(s): 

Oksana Berezovska, PhD

Most Recent/Current Position(s): 

Assistant Professor (Neurology), Harvard Medical School

FE65 Proteins Modulate APP Processing and Function

Project Year(s): 
2004 - 2005
Principal Investigator(s): 

Yang Chang, MD, PhD

Most Recent/Current Position(s): 

Investigator, Wyeth Pharamaceuticals, Inc.

Transcriptional Dysregulation in Dementia with Lewy Bodies

Project Year(s): 
2004 - 2005
Principal Investigator(s): 

Ippolita Cantuti-Castelvetri, PhD

Most Recent/Current Position(s): 

Instructor (Neurology), Harvard Medical School

Characteristics of Cerebral Amyloid Angiopathy and Leukoaraiosis in Alzheimer's Disease and Dementias

Project Year(s): 
2004 - 2005
Principal Investigator(s): 

Alireza Atri, MD, PhD

Most Recent/Current Position(s): 

Associate Director, Center for Translational Cognitive Neuroscience, Geriatric Research Educational Clinical Center/Bedford Veterans Affairs Hospital & Clinical Instructor (Neurology), Harvard Medical School

Beta-Amyloid Deposition in Alzheimer's Disease Lens

Project Year(s): 
2003 - 2004
Principal Investigator(s): 

Lee E. Goldstein, MD, PhD

Most Recent/Current Position(s): 

Director, Molecular Aging and Development Laboratory & Co-Director, Boston University ADC Translational Animal Core & Associate Professor (Psychiatry, Ophthalmology, Neurology, Pathology & Laboratory Medicine, Biomedical Engineering), Boston University

The Insulin-Degrading Enzyme: Its Role in A-Beta and AICD Degradation In Vivo

Project Year(s): 
2003 - 2004
Principal Investigator(s): 

Suzanne Y. Guenette, PhD

Most Recent/Current Position(s): 

Assistant Professor (Neurology), Harvard Medical School

LRP-Mediated Clearance of Pre-Fibrillar Oligomeric A-Beta Species

Project Year(s): 
2003 - 2004
Principal Investigator(s): 

Robert D. Moir, PhD

Most Recent/Current Position(s): 

Assistant Professor (Neurology), Harvard Medical School

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