5-Year Major

Mouse Model of Early Alzheimer's Disease

Project Year(s): 
2014 - 2019
Principal Investigator(s): 

Bradley T. Hyman, MD, PhD

Most Recent/Current Position(s): 

Director, Massachusetts ADRC & John B. Penney, Jr. Professor of Neurology, Harvard Medical School

Brain Amyloid Accrual in Non-Demented People: Preclinical AD or Brain Resilience

Project Year(s): 
2014 - 2019
Principal Investigator(s): 

M. Teresa Gomez-Isla, MD, PhD

Most Recent/Current Position(s): 

Co-Director, Clinical Core, Massachusetts Alzheimer's Disease Research Center & Co-Director, Massachusetts General Hospital Memory Disorders Unit & Associate Professor of Neurology, Harvard Medical School

Neural Correlates of Cognitive Prodromes in Neurodegenerative Dementias

Project Year(s): 
2014 - 2019
Principal Investigator(s): 

Julius (Trey) C. Hedden, III, PhD

Most Recent/Current Position(s): 

Instructor in Radiology, Harvard Medical School

Neuropathological Correlates of Oligomeric Amyloid Beta

Project Year(s): 
2009 - 2014
Principal Investigator(s): 

Bradley T. Hyman, MD, PhD

Most Recent/Current Position(s): 

Director, Massachusetts ADRC & John B. Penney, Jr. Professor of Neurology, Harvard Medical School

The Role of Advanced Cerebral Amyloid Angiopathy in Alzheimer's Dementia

Project Year(s): 
2009 - 2014
Principal Investigator(s): 

Anand Viswanathan, MD, PhD

Most Recent/Current Position(s): 

Associate Director, Telestroke Services, Massachusetts General Hospital Hemorrhagic Stroke Research Program & Assistant Professor of Neurology, Harvard Medical School

Implications of Amyloid Deposits in Clinically Normal Older Individuals

Project Year(s): 
2009 - 2014
Principal Investigator(s): 

Reisa A. Sperling, MD

Most Recent/Current Position(s): 

Director, Clinical Research, Memory Disorders Unit, Brigham and Women's Hospital & Professor of Neurology, Harvard Medical School

Tau Alterations in Alzheimer and Related Dementias

Project Year(s): 
2004 - 2009
Principal Investigator(s): 

Bradley T. Hyman, MD, PhD

Most Recent/Current Position(s): 

Director, Massachusetts ADRC & John B. Penney, Jr. Professor of Neurology, Harvard Medical School

Phosphorylation Control of Tau Neurotoxicity in Drosophila

Project Year(s): 
2004 - 2009
Principal Investigator(s): 

Mel B. Feany, MD, PhD

Most Recent/Current Position(s): 

Professor of Pathology, Harvard Medical School

Genetic Analysis of Alzheimer's Disease

Project Year(s): 
1998 - 2003
Principal Investigator(s): 

Rudolph E. Tanzi, PhD

Most Recent/Current Position(s): 

Director, Genetics & Aging Research Unit, Mass Gen Institute for Neurodegenerative Disease & Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Harvard Medical School

The Role of MAP Kinase in Synaptic Plasticity and Memory

Project Year(s): 
1998 - 2003
Principal Investigator(s): 

Susumu Tonegawa, PhD

Most Recent/Current Position(s): 

1987 Nobel Laureate in Physiology/Medicine & Picower Professor of Biology and Neuroscience, Massachusetts Institute of Technology

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