Prions are the misshapen proteins that replicate by inducing normal proteins to misfold and aggregate in the brain, leading to rare diseases such as mad cow and kuru. In recent years, scientists have discovered that similar processes of protein misfolding are at work in many neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Lou Gehrig’s disease. Now, a study in Nature reveals the first evidence for human-to-human transmission of the misfolded proteins that underlie the pathology of Alzheimer’s disease.
At the age of 93, Olga Kotelko - one of the most successful and acclaimed nonagenarian track-and-field athletes in history - traveled to the University of Illinois to let scientists study her brain.
Ms. Kotelko held a number of world records and had won hundreds of gold medals in masters events. But she was of particular interest to the scientific community because she hadn’t begun serious athletic training until age 77. So scanning her brain could potentially show scientists what late-life exercise might do for brains.
Middle-aged Americans have one more reason to keep an eye on the scale as they age: research shows that people who are overweight when they are 50 years old may be more likely to develop Alzheimer’s sooner than those that are a healthy weight.
Scientists at the National Institutes of Health studied midlife obesity’s connection to Alzheimer’s and announced in a study published Tuesday in the journal Molecular Psychiatry that they had found a connection between being overweight or obese in middle age and developing Alzheimer’s.
With the growing use of biomarkers, researchers can now identify cognitively normal people who are at elevated risk for Alzheimer’s disease. This has enabled secondary prevention studies such as the Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease (A4) trial. To participate in this type of study, however, people typically need to learn about their risk factors. It is not feasible to keep participants blinded on this point, as that would necessitate including many more people, ballooning the cost of these already-expensive undertakings, researchers said.
A small amount of exercise may improve our ability to think as we age, but more may not be better, according to a new study of exercise and cognition.
We all know that working out is good for us. But precisely how much or how little exercise is needed to gain various health benefits, and whether the same dose of exercise that bolsters heart health, for instance, is also ideal for the brain has remained unclear.
A study released Monday of 40 former NFL players between the ages of 40 and 65 found that those who began playing tackle football before the age of 12 faced a higher risk of altered brain development than those who waited until they were older.
The findings, by researchers at Boston University School of Medicine and Brigham and Women’s Hospital, are the first to show a link between repetitive head impacts early in life and structural brain changes later in life, researchers said.
On a good day, Elizabeth Brood wakes up at 4:30 a.m. and goes to the gym before her boyfriend heads to work around 6:15 a.m. She makes coffee, readies her parents' morning medications – making sure to hide her mother's in chunks of bananas and in the cereal bowl – and changes her mother into fresh clothes. She takes her father to a day program, and sometimes a nurse comes to the house to help her care for her mother, giving her a chance to go grocery shopping or run other errands.
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common human neurodegenerative diseases. AD is primarily a dementing disease, and PD is a movement disorder. Together, they affect around 50 million people worldwide, with the vast majority of disease cases being sporadic. Their incidence increases with age. Like most neurodegenerative diseases, AD and PD are caused by the aggregation of a small number of proteins, with filament assemblies constituting the end-point of protein aggregation.
Alzheimer’s may be one of the most frightening health challenges today. Over five million Americans - one in eight age 65 and older and one in three age 85 and older - are living with dementia and we don’t yet have a treatment that can prevent or cure the disease. But these men and women are not alone. They are supported by 15.5 million family members and friends, and there are things we can all do to ease their burden.