Like many people who care for elderly family members at home, Norio Watanabe, 51, struggled to deal with the physical and mental burdens of looking after his father, who had dementia.
For about four years until his father’s death in 2014, everyday life for the single Watanabe was packed with care and work. He woke up at 3 a.m. to prepare a special meal for his father, who had a kidney disease, and changed his diaper before heading for work at a food catering company.
Dvastating brain diseases like Frontotemporal Dementia and Alzheimer’s have been painfully slow to give up their secrets. But behavioral neurologist Brad Dickerson, MD, and his Mass General research team are tracking an important protein that has long eluded measurement in the living brain. Their work may mark a turning point in how such now-incurable conditions are understood and treated.
NIH Reports to the Nation NIH is pleased to present the 2014-2015 Alzheimer’s Disease Progress Report: Advancing Research Toward a Cure. This annual report details NIH-supported and -conducted Alzheimer’s disease research initiatives, objectives, and advances during calendar year 2014 and early 2015. New findings and investments described in this report are organized in categories determined by the Common Alzheimer Disease Research Ontology (CADRO) of the International Alzheimer’s Disease Research Portfolio (IADRP).
MIT chemical engineers and neuroscientists have developed a new way to classify neurons by labeling and imaging the proteins found in each cell. This type of imaging offers clues to each neuron’s function and should help in mapping the human brain, the researchers say.
Scientists say they've found a network of genes and their subsequent mutations that either speed up or delay the onset of Alzheimer's disease. The finding results from a study carried out within a Colombian extended family of 5,000 people descended from one Spaniard. Lead researcher Dr Maurice Arcos-Burgos from the Australian National University in Canberra says that some of the people contracted the disease in their 30s, other developed it in their 70s. The scientist told Newsday how the mutating genes work.
Health care costs can rise dramatically as we age - especially for those who develop long-term conditions like heart disease or dementia. In the United States, most medical costs for people over age 65 are covered by Medicare, a federal health insurance program. But Medicare and other insurers may not cover key expenses, like home care services, medical equipment, and certain nursing home fees. Little has been known about the personal financial toll that end-of-life care can place on people with chronic disorders.
The National Institutes of Health has launched a new initiative to identify biomarkers and track the progression of Alzheimer’s in people with Down syndrome. Many people with Down syndrome have Alzheimer’s-related brain changes in their 30s that can lead to dementia in their 50s and 60s. Little is known about how the disease progresses in this vulnerable group.
Rudolph E. Tanzi, director of the genetics and aging research unit at Massachusetts General Hospital, professor of neurology at Harvard Medical School and a towering figure in the field of Alzheimer’s research, refuses to play the piano. Yes, he’s an exuberantly dedicated musician who seriously considered a musical career before going into science. He’s played keyboards with the rock band Aerosmith and jammed on “The Tonight Show with Jay Leno.” He practices every day at home on his handmade Bösendorfer concert grand.
Reisa Sperling, HMS professor of neurology at Brigham and Women's Hospital, shares her family's personal connection with Alzheimer's disease and describes ongoing research into early diagnosis and intervention.
And in this episode's abstract, researchers in the lab of George Church use the gene-editing tool CRISPR to inactivate retroviruses in the pig genome with the hope of one day making organs safer for transplant into humans.