Scientists in the United States have managed to turn human embryonic stem cells into a type of brain cell linked to memory loss in Alzheimer's disease. The research, published in the journal Stem Cells, should help in the development and testing of potential new medicines to treat the neurodegenerative disease which affects around half a million people in the UK.
People with an immediate family history of Alzheimer's disease are four to 10 times as likely to contract the condition. A new study now suggests the chances of getting Alzheimer's are higher if your mother had it than if your father had it.
Jeffrey Burns, the director of the University of Kansas Medical Center's Alzheimer's and Memory Program, said the findings don't mean that children of mothers with Alzheimer's disease will develop the condition. "It's not clear on an individual basis how much this risk applies," he said.
The 25th anniversary presentation of the MetLife Foundation Awards for Medical Research in Alzheimer's Disease (AD) was held today honoring two noted researchers, Randy L. Buckner, PhD, Professor of Psychology and of Neuroscience at Harvard University and Howard Hughes Medical Institute investigator, and Marcus E. Raichle, MD, Professor of Radiology and Neurology at Washington University School of Medicine in St. Louis. Both have been pioneers in the area of brain imaging leading to inroads in the study of Alzheimer's.
A new survey by MetLife Foundation finds that Alzheimer's disease is the second most feared disease among American adults, behind only cancer. When asked which of five major diseases they are most afraid, 31% said Alzheimer's, while 41% said cancer. Heart disease and stroke were named by 8% each, while only 6% said they fear diabetes most.
Their mission was to solve a small but nagging mystery of Alzheimer's disease: How would the brain's ability to store information be affected if they "turned off" the obscure protein LRP1?
But Guojun Bu and his fellow researchers were in for a surprise. As they expected, mice whose brains had been wiped of the LRP1 gene showed Alzheimer's-like memory problems. But they also started to put on weight - fast.
The mice were lethargic. They were on their way to becoming diabetic. And they didn't seem to know when to stop eating.
Scientists at the Harvard-affiliated Dana-Farber Cancer Institute say they have identified the root molecular cause of a variety of ills brought on by advanced age, including waning energy, failure of the heart and other organs, and metabolic disorders such as diabetes.
Invite your friends over, gather loved ones, serve some good munchies, and settle in for a night of TV well worth watching. Starting next Saturday, January 29, 2011, CNN will air a documentary film by Felipe Barral. It will focus the attention of viewers around the globe on the terrible scourge that is familial Alzheimer's disease. But more than that, it also showcases a wave of international momentum that is building among inspiring families, committed doctors, scientists - and hopefully industry and regulators - to stop the disease with prevention and therapeutic trials.
The launch of the International Genomics of Alzheimer's Project (IGAP) - a collaboration formed to discover and map the genes that contribute to Alzheimer's disease - was announced today by a multi-national group of researchers. The collaborative effort, spanning universities from both Europe and the United States, will combine the knowledge, staff and resources of four consortia that conduct research on Alzheimer's disease genetics.
Researchers have been able to see changes deep within the brains of living animals at the cellular level. The advance could provide an important tool for understanding diseases and disorders of the brain, including substance abuse and addiction.