Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common human neurodegenerative diseases. AD is primarily a dementing disease, and PD is a movement disorder. Together, they affect around 50 million people worldwide, with the vast majority of disease cases being sporadic. Their incidence increases with age. Like most neurodegenerative diseases, AD and PD are caused by the aggregation of a small number of proteins, with filament assemblies constituting the end-point of protein aggregation.
Alzheimer’s may be one of the most frightening health challenges today. Over five million Americans - one in eight age 65 and older and one in three age 85 and older - are living with dementia and we don’t yet have a treatment that can prevent or cure the disease. But these men and women are not alone. They are supported by 15.5 million family members and friends, and there are things we can all do to ease their burden.
At the annual Alzheimer’s Association International Conference in July 2015, scientists report some encouraging news about the benefits of exercise. In the first studies to look at physical activity among people already diagnosed with the early stages of Alzheimer’s, moderate to high intensity workouts may not only slow down the biological symptoms of Alzheimer’s—but may lead to improvements in cognitive functions as well.
Women who develop slight but detectable deficits in memory and mental acuity late in life tend to decline faster than men with mild impairment, researchers reported on Tuesday.
Some two-thirds of the five million Americans with Alzheimer’s disease are women, a disparity that is partly because women live longer. Researchers have searched in vain for decades to determine other reasons.
Type 2 diabetes is known to put individuals at risk for numerous health complications. Now, a study led by researchers at Harvard Medical School and Beth Israel Deaconess Medical Center sheds new light on the often-overlooked toll that diabetes can take on brain health.
This study found that over a period of just two years, older adults with Type 2 diabetes developed complications in blood flow regulation in the brain that led to impaired memory and other cognitive problems.
Alzheimer's disease seems to develop differently in the brains of black patients than in whites. And, black people seem more likely to suffer different types of brain changes that also contribute to dementia, a new study reports.
Alzheimer's disease dementia is generally associated with a build-up of substances known as plaques and tangles inside the brain. But, there are other brain changes that can also contribute to dementia, the study authors noted.
Ultra-high resolution imaging tools like 7-Tesla MRI now allowresearchers to glimpse the brain in extraordinary detail, openingthe door to new diagnosis and treatment of neurological disorders.
Two imaging advances in particular – focused ultrasound andneuroimaging diagnostics in neurodegenerative and psychiatricillnesses – were featured in the 2015 Disruptive Dozen, the listof 12 technologies predicted to have the greatest impact onneurological care in the coming decade by Partners faculty.
When Jamie Tyrone found out that she carries a gene that gives her a 91 percent chance of developing Alzheimer’s disease beginning around age 65, she sank into a depression so deep that at times she wanted to end her life.
Tyrone, a registered nurse who lives in San Diego, decided to fight back. She exercised, changed her diet, and began taking supplements, including fish oil, vitamin D, vitamin B12, curcumin, turmeric, and an antioxidant called CoQ10.
We will be posting a new pay line for Alzheimer’s research, and I want to alert you to two important facts around it. First, the new pay lines are nine percentage points higher than our general RPG pay line and show advantages in other lines too, such as career awards and small business research. Second, we are now coding applications as Alzheimer’s when the NIH Research, Condition, and Disease Categorization (RCDC) coding system includes the proposed work in the Alzheimer’s category.