Understanding who is most susceptible to Alzheimer's disease and developing early detection models, effective therapies and possibly a cure, is the goal of the largest single private scientific grant ever invested in Alzheimer's Whole Genome Sequencing (WGS) focused on families afficted with Alzheimer's disease.
A $5.4 million contribution announced today from the non-profit Cure Alzheimer's Fund to Massachusetts General Hospital (MGH) will allow state-of-the-art whole genome DNA sequencing to further understand the genetic roots of Alzheimer's disease.
A century and a half ago, French physician Pierre Paul Broca found that patients with damage to part of the brain's frontal lobe were unable to speak more than a few words. Later dubbed Broca's area, this region is believed to be critical for speech production and some aspects of language comprehension.
More than 5 million Americans have Alzheimer's disease, and the nonprofit Alzheimer's Association projects that, barring major advances, 11 million to 16 million will have it by 2050 - at an annual cost of $1.1 trillion in today's dollars. In May, the government announced the first national plan to combat Alzheimer's, and one focus is the role of beta-amyloid plaques in the brain, a leading suspect in this form of dementia. U.S.
Researchers investigating a known gene risk factor for Alzheimer's dsiease discovered it is associated with lower levels of beta amyloid - a brain protein involved in Alzheimer's - in cognitively healthy older people. The findings suggest that a mechanism other than one related to beta amyloid accumulation may influence disease risk associated with the gene. The study, by researchers at the National Institute on Aging (NIA) at the National Institutes of Health, was published online September 27, 2012 in the journal Biological Psychiatry.
Teresa Gómez Isla estuvo este verano dando un curso magistral sobre la enfermedad de Alzheimer en la Universidad Internacional Menéndez Pelayo, en Santander.
Ahora, desde Boston, esta investigadora, quien ha tratado al expresidente de la Generalitat catalana Pasqual Maragall, que sufre alzhéimer desde 2007, habla con EFEsalud para analizar esta grave enfermedad.
YOU die alone, philosophers say. But you could die sooner if you live your life in loneliness. Close connections to friends and family may ward off poor health and premature death, recent research suggests.
With an Alzheimer's epidemic looming, scientists, health officials, policymakers and the public are asking if anything can slow down this disease. Some prevention trials in the U.S. will test drug interventions but what about lifestyle modifications, such as eating better or exercising more? Some data suggest that tweaks in our routine could help, but in 2010 a panel from the National Institutes of Health deemed that evidence insufficient to justify formal recommendations.