Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed.
Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster, and then used gene therapy to lengthen telomeres - compounds found at the ends of strands of DNA - which reversed age-related problems such as decreased brain function and infertility.
A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer's disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health. The study found that the drug, diazoxide, acted on nerve cells in the mouse brain in ways that slowed the development of the neurodegenerative disorder. The findings appear in the Nov 15 2010 print edition of the Journal of Alzheimer's Disease.
Bruce Vincent works his way up and down the aisles of the grocery store he has owned for two decades, methodically unpacking crates of food, stocking shelves, and breaking down the empty cartons.
Midway down aisle 2, Vincent hesitates, unsure where the fudge-coated peanuet butter cookies go. The redesigned package throws him, so he tucks them amid crackers on the top shelf and continues down the row.
Renee Packel used to have a typical suburban life. Her husband, Arthur, was a lawyer and also sold insurance. They lived in a town house just outside Philadelphia, and Mrs. Packel took care of their home and family.
One day, it all came crashing down. The homeowners’ association called asking for their fees. To Mrs. Packel’s surprise, her husband had simply stopped paying them. Then she learned he had stopped writing checks to his creditors, too.
Under the microscope, the tan image with brown splotches resembles a burned map, its edges singed and riddled with dark squiggles that shouldn't be there. This is a piece of brain from a 45-year-old man: Former National Football League linebacker John Grimsley, who suited up for the Houston Oilers for nine years and absorbed at least 11 concussions during professional and college play.