He did two crossword puzzles a day, sometimes more, working through the list of clues in strict order, as if to remember where he was.
And, perhaps, what he was doing.
Henry Gustav Molaison - known through most of his life only as H.M., to protect his privacy - became the most studied patient in the history of brain science after 1953, when an experimental brain operation left him, at age 27, unable to form new memories.
Scientists have turned back the clock in mice they engineered to age faster than normal, an advance they suggest is the first time aging in mice has been reversed.
Researchers at Harvard-affiliated medical centers genetically manipulated mice to age faster, and then used gene therapy to lengthen telomeres - compounds found at the ends of strands of DNA - which reversed age-related problems such as decreased brain function and infertility.
A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer's disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health. The study found that the drug, diazoxide, acted on nerve cells in the mouse brain in ways that slowed the development of the neurodegenerative disorder. The findings appear in the Nov 15 2010 print edition of the Journal of Alzheimer's Disease.
Bruce Vincent works his way up and down the aisles of the grocery store he has owned for two decades, methodically unpacking crates of food, stocking shelves, and breaking down the empty cartons.
Midway down aisle 2, Vincent hesitates, unsure where the fudge-coated peanuet butter cookies go. The redesigned package throws him, so he tucks them amid crackers on the top shelf and continues down the row.