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2015
J. M. Mc Donald, O'Malley, T. T., Liu, W., Mably, A. J., Brinkmalm, G., Portelius, E., Wittbold, W. M., Frosch, M. P., and Walsh, D. M., The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species., Alzheimers Dement, vol. 11, no. 11, pp. 1286-305, 2015.
B. L. Miller, Dickerson, B. C., Lucente, D. E., Larvie, M., and Frosch, M. P., Case records of the Massachusetts General Hospital. Case 9-2015. A 31-year-old man with personality changes and progressive neurologic decline., N Engl J Med, vol. 372, no. 12, pp. 1151-62, 2015.
J. Eugenio Iglesias, Augustinack, J. C., Nguyen, K., Player, C. M., Player, A., Wright, M., Roy, N., Frosch, M. P., McKee, A. C., Wald, L. L., Fischl, B., and Van Leemput, K., A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI., Neuroimage, vol. 115, pp. 117-37, 2015.
S. Martinez-Ramirez, Romero, J. - R., Shoamanesh, A., McKee, A. C., Van Etten, E., Pontes-Neto, O., Macklin, E. A., Ayres, A., Auriel, E., Himali, J. J., Beiser, A. S., DeCarli, C., Stein, T. D., Alvarez, V. E., Frosch, M. P., Rosand, J., Greenberg, S. M., M Gurol, E., Seshadri, S., and Viswanathan, A., Diagnostic value of lobar microbleeds in individuals without intracerebral hemorrhage., Alzheimers Dement, vol. 11, no. 12, pp. 1480-8, 2015.
E. Auriel, M Westover, B., Bianchi, M. T., Reijmer, Y., Martinez-Ramirez, S., Ni, J., Van Etten, E., Frosch, M. P., Fotiadis, P., Schwab, K., Vashkevich, A., Boulouis, G., Younger, A. P., Johnson, K. A., Sperling, R. A., Hedden, T., M Gurol, E., Viswanathan, A., and Greenberg, S. M., Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging., Stroke, vol. 46, no. 8, pp. 2129-35, 2015.
L. B. Wood, Winslow, A. R., Proctor, E. A., McGuone, D., Mordes, D. A., Frosch, M. P., Hyman, B. T., Lauffenburger, D. A., and Haigis, K. M., Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening., Sci Rep, vol. 5, p. 16622, 2015.
L. Zhao, Arbel-Ornath, M., Wang, X., Betensky, R. A., Greenberg, S. M., Frosch, M. P., and Bacskai, B. J., Matrix metalloproteinase 9-mediated intracerebral hemorrhage induced by cerebral amyloid angiopathy., Neurobiol Aging, vol. 36, no. 11, pp. 2963-71, 2015.
S. Takeda, Wegmann, S., Cho, H., DeVos, S. L., Commins, C., Roe, A. D., Nicholls, S. B., Carlson, G. A., Pitstick, R., Nobuhara, C. K., Costantino, I., Frosch, M. P., Müller, D. J., Irimia, D., and Hyman, B. T., Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain., Nat Commun, vol. 6, p. 8490, 2015.
C. Magnain, Augustinack, J. C., Konukoglu, E., Frosch, M. P., Sakadžić, S., Varjabedian, A., Garcia, N., Wedeen, V. J., Boas, D. A., and Fischl, B., Optical coherence tomography visualizes neurons in human entorhinal cortex., Neurophotonics, vol. 2, no. 1, p. 015004, 2015.
G. W. Beecham, Dickson, D. W., Scott, W. K., Martin, E. R., Schellenberg, G., Nuytemans, K., Larson, E. B., Buxbaum, J. D., Trojanowski, J. Q., Van Deerlin, V. M., Hurtig, H. I., Mash, D. C., Beach, T. G., Troncoso, J. C., Pletnikova, O., Frosch, M. P., Ghetti, B., Foroud, T. M., Honig, L. S., Marder, K., Vonsattel, J. Paul, Goldman, S. M., Vinters, H. V., Ross, O. A., Wszolek, Z. K., Wang, L., Dykxhoorn, D. M., Pericak-Vance, M. A., Montine, T. J., Leverenz, J. B., Dawson, T. M., and Vance, J. M., PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease., Neurology, vol. 84, no. 10, pp. 972-80, 2015.
L. - San Wang, Naj, A. C., Graham, R. R., Crane, P. K., Kunkle, B. W., Cruchaga, C., Murcia, J. D. Gonzalez, Cannon-Albright, L., Baldwin, C. T., Zetterberg, H., Blennow, K., Kukull, W. A., Faber, K. M., Schupf, N., Norton, M. C., Tschanz, J. A. T., Munger, R. G., Corcoran, C. D., Rogaeva, E., Lin, C. - F., Dombroski, B. A., Cantwell, L. B., Partch, A., Valladares, O., Hakonarson, H., St George-Hyslop, P., Green, R. C., Goate, A. M., Foroud, T. M., Carney, R. M., Larson, E. B., Behrens, T. W., Kauwe, J. S. K., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Mayeux, R., Schellenberg, G. D., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barmada, M., Barnes, L. L., Beach, T. G., Becker, J. T., Beecham, G. W., Beekly, D., Bennett, D. A., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., F Demirci, Y., Dick, M., Dickson, D. W., Duara, R., Ertekin-Taner, N., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Graff-Radford, N. R., Growdon, J. H., Hamilton, R. L., Hamilton-Nelson, K. L., Harrell, L. E., Head, E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. - W., Jun, G., Jun, G., M Kamboh, I., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lopez, O. L., Lunetta, K. L., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martin, E. R., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., W Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Murrell, J. R., Olichney, J. M., Parisi, J. E., Perry, W., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rosen, H. J., Rosenberg, R. N., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. Paul, Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. - E., and Yu, L., Rarity of the Alzheimer disease-protective APP A673T variant in the United States., JAMA Neurol, vol. 72, no. 2, pp. 209-16, 2015.
E. Murray, Cho, J. Hun, Goodwin, D., Ku, T., Swaney, J., Kim, S. - Y., Choi, H., Park, Y. - G., Park, J. - Y., Hubbert, A., McCue, M., Vassallo, S., Bakh, N., Frosch, M. P., Wedeen, V. J., H Seung, S., and Chung, K., Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems., Cell, vol. 163, no. 6, pp. 1500-14, 2015.
M. Marquié, Normandin, M. D., Vanderburg, C. R., Costantino, I. M., Bien, E. A., Rycyna, L. G., Klunk, W. E., Mathis, C. A., Ikonomovic, M. D., Debnath, M. L., Vasdev, N., Dickerson, B. C., Gomperts, S. N., Growdon, J. H., Johnson, K. A., Frosch, M. P., Hyman, B. T., and Gómez-Isla, T., Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue., Ann Neurol, vol. 78, no. 5, pp. 787-800, 2015.
2014
K. Nuytemans, Inchausti, V., Beecham, G. W., Wang, L., Dickson, D. W., Trojanowski, J. Q., Lee, V. M. - Y., Mash, D. C., Frosch, M. P., Foroud, T. M., Honig, L. S., Montine, T. J., Dawson, T. M., Martin, E. R., Scott, W. K., and Vance, J. M., Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease., Mov Disord, vol. 29, no. 6, pp. 827-30, 2014.
A. C. Naj, Jun, G., Reitz, C., Kunkle, B. W., Perry, W., Park, Y. Son, Beecham, G. W., Rajbhandary, R. A., Hamilton-Nelson, K. L., San Wang, L. -, Kauwe, J. S. K., Huentelman, M. J., Myers, A. J., Bird, T. D., Boeve, B. F., Baldwin, C. T., Jarvik, G. P., Crane, P. K., Rogaeva, E., M Barmada, M., F Demirci, Y., Cruchaga, C., Kramer, P. L., Ertekin-Taner, N., Hardy, J., Graff-Radford, N. R., Green, R. C., Larson, E. B., St George-Hyslop, P. H., Buxbaum, J. D., Evans, D. A., Schneider, J. A., Lunetta, K. L., M Kamboh, I., Saykin, A. J., Reiman, E. M., De Jager, P. L., Bennett, D. A., Morris, J. C., Montine, T. J., Goate, A. M., Blacker, D., Tsuang, D. W., Hakonarson, H., Kukull, W. A., Foroud, T. M., Martin, E. R., Haines, J. L., Mayeux, R. P., Farrer, L. A., Schellenberg, G. D., Pericak-Vance, M. A., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barnes, L. L., Beach, T. G., Becker, J. T., Beekly, D., Bigio, E. H., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Cantwell, L. B., Cao, C., Carlson, C. S., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., Dick, M., Dickson, D. W., Duara, R., Faber, K. M., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jicha, G. A., Jin, L. - W., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lin, C. - F., Lopez, O. L., Lyketsos, C. G., Mack, W. J., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Murrell, J. R., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Paulson, H. L., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Ringman, J. M., Roberson, E. D., Rosen, H. J., Rosenberg, R. N., Sano, M., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Valladares, O., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. Paul, Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. - E., and Yu, L., Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study., JAMA Neurol, vol. 71, no. 11, pp. 1394-404, 2014.
H. - C. Tai, Wang, B. Y., Serrano-Pozo, A., Frosch, M. P., Spires-Jones, T. L., and Hyman, B. T., Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease., Acta Neuropathol Commun, vol. 2, p. 146, 2014.
G. W. Beecham, Hamilton, K., Naj, A. C., Martin, E. R., Huentelman, M., Myers, A. J., Corneveaux, J. J., Hardy, J., Vonsattel, J. - P., Younkin, S. G., Bennett, D. A., De Jager, P. L., Larson, E. B., Crane, P. K., M Kamboh, I., Kofler, J. K., Mash, D. C., Duque, L., Gilbert, J. R., Gwirtsman, H., Buxbaum, J. D., Kramer, P., Dickson, D. W., Farrer, L. A., Frosch, M. P., Ghetti, B., Haines, J. L., Hyman, B. T., Kukull, W. A., Mayeux, R. P., Pericak-Vance, M. A., Schneider, J. A., Trojanowski, J. Q., Reiman, E. M., Schellenberg, G. D., and Montine, T. J., Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias., PLoS Genet, vol. 10, no. 9, p. e1004606, 2014.
A. Serrano-Pozo, Qian, J., Monsell, S. E., Blacker, D., Gómez-Isla, T., Betensky, R. A., Growdon, J. H., Johnson, K. A., Frosch, M. P., Sperling, R. A., and Hyman, B. T., Mild to moderate Alzheimer dementia with insufficient neuropathological changes., Ann Neurol, vol. 75, no. 4, pp. 597-601, 2014.
E. N. Bit-Ivan, Suh, E., Shim, H. - S., Weintraub, S., Hyman, B. T., Arnold, S. E., McCarty-Wood, E., Van Deerlin, V. M., Schneider, J. A., Trojanowski, J. Q., Frosch, M. P., Baker, M. C., Rademakers, R., Mesulam, M., and Bigio, E. H., A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases., J Neuropathol Exp Neurol, vol. 73, no. 5, pp. 467-73, 2014.
M. D. Gallagher, Suh, E., Grossman, M., Elman, L., McCluskey, L., van Swieten, J. C., Al-Sarraj, S., Neumann, M., Gelpi, E., Ghetti, B., Rohrer, J. D., Halliday, G., Van Broeckhoven, C., Seilhean, D., Shaw, P. J., Frosch, M. P., Alafuzoff, I., Antonell, A., Bogdanovic, N., Brooks, W., Cairns, N. J., Cooper-Knock, J., Cotman, C., Cras, P., Cruts, M., De Deyn, P. P., DeCarli, C., Dobson-Stone, C., Engelborghs, S., Fox, N., Galasko, D., Gearing, M., Gijselinck, I., Grafman, J., Hartikainen, P., Hatanpaa, K. J., J Highley, R., Hodges, J., Hulette, C., Ince, P. G., Jin, L. - W., Kirby, J., Kofler, J., Kril, J., Kwok, J. B. J., Levey, A., Lieberman, A., Lladó, A., Martin, J. - J., Masliah, E., McDermott, C. J., McKee, A., McLean, C., Mead, S., Miller, C. A., Miller, J., Munoz, D. G., Murrell, J., Paulson, H., Piguet, O., Rossor, M., Sánchez-Valle, R., Sano, M., Schneider, J., Silbert, L. C., Spina, S., van der Zee, J., Van Langenhove, T., Warren, J., Wharton, S. B., White, C. L., Woltjer, R. L., Trojanowski, J. Q., M Y Lee, V., Van Deerlin, V., and Chen-Plotkin, A. S., TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions., Acta Neuropathol, vol. 127, no. 3, pp. 407-18, 2014.

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