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2016
D. M. Rentz, Dekhtyar, M., Sherman, J., Burnham, S., Blacker, D., Aghjayan, S. L., Papp, K. V., Amariglio, R. E., Schembri, A., Chenhall, T., Maruff, P., Aisen, P., Hyman, B. T., and Sperling, R. A., The Feasibility of At-Home iPad Cognitive Testing For Use in Clinical Trials., J Prev Alzheimers Dis, vol. 3, no. 1, pp. 8-12, 2016.
T. J. Montine, Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., Lee, E. B., Nelson, P. T., Schantz, A. M., Schneider, J. A., Sonnen, J. A., Trojanowski, J. Q., Vinters, H. V., Zhou, X. - H., and Hyman, B. T., Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease., Alzheimers Dement, vol. 12, no. 2, pp. 164-9, 2016.
A. Serrano-Pozo, Betensky, R. A., Frosch, M. P., and Hyman, B. T., Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease., Am J Pathol, vol. 186, no. 2, pp. 375-84, 2016.
S. Takeda, Commins, C., DeVos, S. L., Nobuhara, C. K., Wegmann, S., Roe, A. D., Costantino, I., Fan, Z., Nicholls, S. B., Sherman, A. E., Lipsanopoulos, A. T. Trisini, Scherzer, C. R., Carlson, G. A., Pitstick, R., Peskind, E. R., Raskind, M. A., Li, G., Montine, T. J., Frosch, M. P., and Hyman, B. T., Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients., Ann Neurol, vol. 80, no. 3, pp. 355-67, 2016.
2015
J. B. Toledo, Zetterberg, H., van Harten, A. C., Glodzik, L., Martinez-Lage, P., Bocchio-Chiavetto, L., Rami, L., Hansson, O., Sperling, R., Engelborghs, S., Osorio, R. S., Vanderstichele, H., Vandijck, M., Hampel, H., Teipl, S., Moghekar, A., Albert, M., Hu, W. T., Argilés, J. A. Monge, Gorostidi, A., Teunissen, C. E., De Deyn, P. P., Hyman, B. T., Molinuevo, J. L., Frisoni, G. B., Linazasoro, G., de Leon, M. J., van der Flier, W. M., Scheltens, P., Blennow, K., Shaw, L. M., and Trojanowski, J. Q., Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects., Brain, vol. 138, no. Pt 9, pp. 2701-15, 2015.
A. M. Pooler, Polydoro, M., Maury, E. A., Nicholls, S. B., Reddy, S. M., Wegmann, S., William, C., Saqran, L., Cagsal-Getkin, O., Pitstick, R., Beier, D. R., Carlson, G. A., Spires-Jones, T. L., and Hyman, B. T., Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease., Acta Neuropathol Commun, vol. 3, p. 14, 2015.
A. Serrano-Pozo, Qian, J., Monsell, S. E., Betensky, R. A., and Hyman, B. T., APOEε2 is associated with milder clinical and pathological Alzheimer disease., Ann Neurol, vol. 77, no. 6, pp. 917-29, 2015.
J. J. Locascio, Eberly, S., Liao, Z., Liu, G., Hoesing, A. N., Duong, K., Trisini-Lipsanopoulos, A., Dhima, K., Hung, A. Y., Flaherty, A. W., Schwarzschild, M. A., Hayes, M. T., Wills, A. - M., U Sohur, S., Mejia, N. I., Selkoe, D. J., Oakes, D., Shoulson, I., Dong, X., Marek, K., Zheng, B., Ivinson, A., Hyman, B. T., Growdon, J. H., Sudarsky, L. R., Schlossmacher, M. G., Ravina, B., and Scherzer, C. R., Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease., Brain, vol. 138, no. Pt 9, pp. 2659-71, 2015.
M. W. Albers, Gilmore, G. C., Kaye, J., Murphy, C., Wingfield, A., Bennett, D. A., Boxer, A. L., Buchman, A. S., Cruickshanks, K. J., Devanand, D. P., Duffy, C. J., Gall, C. M., Gates, G. A., Granholm, A. - C., Hensch, T., Holtzer, R., Hyman, B. T., Lin, F. R., McKee, A. C., Morris, J. C., Petersen, R. C., Silbert, L. C., Struble, R. G., Trojanowski, J. Q., Verghese, J., Wilson, D. A., Xu, S., and Zhang, L. I., At the interface of sensory and motor dysfunctions and Alzheimer's disease., Alzheimers Dement, vol. 11, no. 1, pp. 70-98, 2015.
Y. Yang, C Keene, D., Peskind, E. R., Galasko, D. R., Hu, S. - C., Cudaback, E., Wilson, A. M., Li, G., Yu, C. - E., Montine, K. S., Zhang, J., Baird, G. S., Hyman, B. T., and Montine, T. J., Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease., J Neuropathol Exp Neurol, vol. 74, no. 7, pp. 672-87, 2015.
Y. Hori, Takeda, S., Cho, H., Wegmann, S., Shoup, T. M., Takahashi, K., Irimia, D., Elmaleh, D. R., Hyman, B. T., and Hudry, E., A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease., J Biol Chem, vol. 290, no. 4, pp. 1966-78, 2015.
B. von Einem, Wahler, A., Schips, T., Serrano-Pozo, A., Proepper, C., Boeckers, T. M., Rueck, A., Wirth, T., Hyman, B. T., Danzer, K. M., Thal, D. R., and von Arnim, C. A. F., The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1)., PLoS One, vol. 10, no. 6, p. e0129047, 2015.
T. Yang, O'Malley, T. T., Kanmert, D., Jerecic, J., Zieske, L. R., Zetterberg, H., Hyman, B. T., Walsh, D. M., and Selkoe, D. J., A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid., Alzheimers Res Ther, vol. 7, no. 1, p. 14, 2015.
L. B. Wood, Winslow, A. R., Proctor, E. A., McGuone, D., Mordes, D. A., Frosch, M. P., Hyman, B. T., Lauffenburger, D. A., and Haigis, K. M., Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening., Sci Rep, vol. 5, p. 16622, 2015.
B. T. Hyman, Growdon, J. H., Albers, M. W., Buckner, R. L., Chhatwal, J., Gomez-Isla, M. Teresa, Haass, C., Hudry, E., Jack, C. R., Johnson, K. A., Khachaturian, Z. S., Kim, D. Yeon, Martin, J. B., Nitsch, R. M., Rosen, B. R., Selkoe, D. J., Sperling, R. A., St George-Hyslop, P., Tanzi, R. E., Yap, L., Young, A. B., Phelps, C. H., and McCaffrey, P. G., Massachusetts Alzheimer's Disease Research Center: progress and challenges., Alzheimers Dement, vol. 11, no. 10, pp. 1241-5, 2015.
S. Takeda, Wegmann, S., Cho, H., DeVos, S. L., Commins, C., Roe, A. D., Nicholls, S. B., Carlson, G. A., Pitstick, R., Nobuhara, C. K., Costantino, I., Frosch, M. P., Müller, D. J., Irimia, D., and Hyman, B. T., Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain., Nat Commun, vol. 6, p. 8490, 2015.
M. Arimon, Takeda, S., Post, K. L., Svirsky, S., Hyman, B. T., and Berezovska, O., Oxidative stress and lipid peroxidation are upstream of amyloid pathology., Neurobiol Dis, vol. 84, pp. 109-19, 2015.
R. S. Desikan, Schork, A. J., Wang, Y., Thompson, W. K., Dehghan, A., Ridker, P. M., Chasman, D. I., McEvoy, L. K., Holland, D., Chen, C. - H., Karow, D. S., Brewer, J. B., Hess, C. P., Williams, J., Sims, R., O'Donovan, M. C., Choi, S. Hoan, Bis, J. C., M Ikram, A., Gudnason, V., DeStefano, A. L., van der Lee, S. J., Psaty, B. M., van Duijn, C. M., Launer, L., Seshadri, S., Pericak-Vance, M. A., Mayeux, R., Haines, J. L., Farrer, L. A., Hardy, J., Ulstein, I. Dina, Aarsland, D., Fladby, T., White, L. R., Sando, S. B., Rongve, A., Witoelar, A., Djurovic, S., Hyman, B. T., Snaedal, J., Steinberg, S., Stefansson, H., Stefansson, K., Schellenberg, G. D., Andreassen, O. A., and Dale, A. M., Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease., Circulation, vol. 131, no. 23, pp. 2061-9, 2015.
L. - San Wang, Naj, A. C., Graham, R. R., Crane, P. K., Kunkle, B. W., Cruchaga, C., Murcia, J. D. Gonzalez, Cannon-Albright, L., Baldwin, C. T., Zetterberg, H., Blennow, K., Kukull, W. A., Faber, K. M., Schupf, N., Norton, M. C., Tschanz, J. A. T., Munger, R. G., Corcoran, C. D., Rogaeva, E., Lin, C. - F., Dombroski, B. A., Cantwell, L. B., Partch, A., Valladares, O., Hakonarson, H., St George-Hyslop, P., Green, R. C., Goate, A. M., Foroud, T. M., Carney, R. M., Larson, E. B., Behrens, T. W., Kauwe, J. S. K., Haines, J. L., Farrer, L. A., Pericak-Vance, M. A., Mayeux, R., Schellenberg, G. D., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barmada, M., Barnes, L. L., Beach, T. G., Becker, J. T., Beecham, G. W., Beekly, D., Bennett, D. A., Bigio, E. H., Bird, T. D., Blacker, D., Boeve, B. F., Bowen, J. D., Boxer, A., Burke, J. R., Buxbaum, J. D., Cairns, N. J., Cao, C., Carlson, C. S., Carroll, S. L., Chui, H. C., Clark, D. G., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., F Demirci, Y., Dick, M., Dickson, D. W., Duara, R., Ertekin-Taner, N., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Graff-Radford, N. R., Growdon, J. H., Hamilton, R. L., Hamilton-Nelson, K. L., Harrell, L. E., Head, E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jarvik, G. P., Jicha, G. A., Jin, L. - W., Jun, G., Jun, G., M Kamboh, I., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lopez, O. L., Lunetta, K. L., Lyketsos, C. G., Mack, W. J., Marson, D. C., Martin, E. R., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., W Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Montine, T. J., Morris, J. C., Murrell, J. R., Olichney, J. M., Parisi, J. E., Perry, W., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reiman, E. M., Reisberg, B., Reitz, C., Ringman, J. M., Roberson, E. D., Rosen, H. J., Rosenberg, R. N., Sano, M., Saykin, A. J., Schneider, J. A., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Tsuang, D. W., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. Paul, Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. - E., and Yu, L., Rarity of the Alzheimer disease-protective APP A673T variant in the United States., JAMA Neurol, vol. 72, no. 2, pp. 209-16, 2015.
S. Wegmann, Maury, E. A., Kirk, M. J., Saqran, L., Roe, A., DeVos, S. L., Nicholls, S., Fan, Z., Takeda, S., Cagsal-Getkin, O., William, C. M., Spires-Jones, T. L., Pitstick, R., Carlson, G. A., Pooler, A. M., and Hyman, B. T., Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity., EMBO J, vol. 34, no. 24, pp. 3028-41, 2015.
Y. Hori, Hashimoto, T., Nomoto, H., Hyman, B. T., and Iwatsubo, T., Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO., J Biol Chem, vol. 290, no. 24, pp. 15163-74, 2015.
E. Galea, Morrison, W., Hudry, E., Arbel-Ornath, M., Bacskai, B. J., Gómez-Isla, T., H Stanley, E., and Hyman, B. T., Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques., Proc Natl Acad Sci U S A, vol. 112, no. 51, pp. 15556-61, 2015.
M. Marquié, Normandin, M. D., Vanderburg, C. R., Costantino, I. M., Bien, E. A., Rycyna, L. G., Klunk, W. E., Mathis, C. A., Ikonomovic, M. D., Debnath, M. L., Vasdev, N., Dickerson, B. C., Gomperts, S. N., Growdon, J. H., Johnson, K. A., Frosch, M. P., Hyman, B. T., and Gómez-Isla, T., Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue., Ann Neurol, vol. 78, no. 5, pp. 787-800, 2015.
2014
A. C. Naj, Jun, G., Reitz, C., Kunkle, B. W., Perry, W., Park, Y. Son, Beecham, G. W., Rajbhandary, R. A., Hamilton-Nelson, K. L., San Wang, L. -, Kauwe, J. S. K., Huentelman, M. J., Myers, A. J., Bird, T. D., Boeve, B. F., Baldwin, C. T., Jarvik, G. P., Crane, P. K., Rogaeva, E., M Barmada, M., F Demirci, Y., Cruchaga, C., Kramer, P. L., Ertekin-Taner, N., Hardy, J., Graff-Radford, N. R., Green, R. C., Larson, E. B., St George-Hyslop, P. H., Buxbaum, J. D., Evans, D. A., Schneider, J. A., Lunetta, K. L., M Kamboh, I., Saykin, A. J., Reiman, E. M., De Jager, P. L., Bennett, D. A., Morris, J. C., Montine, T. J., Goate, A. M., Blacker, D., Tsuang, D. W., Hakonarson, H., Kukull, W. A., Foroud, T. M., Martin, E. R., Haines, J. L., Mayeux, R. P., Farrer, L. A., Schellenberg, G. D., Pericak-Vance, M. A., Albert, M. S., Albin, R. L., Apostolova, L. G., Arnold, S. E., Barber, R., Barnes, L. L., Beach, T. G., Becker, J. T., Beekly, D., Bigio, E. H., Bowen, J. D., Boxer, A., Burke, J. R., Cairns, N. J., Cantwell, L. B., Cao, C., Carlson, C. S., Carney, R. M., Carrasquillo, M. M., Carroll, S. L., Chui, H. C., Clark, D. G., Corneveaux, J., Cribbs, D. H., Crocco, E. A., DeCarli, C., DeKosky, S. T., Dick, M., Dickson, D. W., Duara, R., Faber, K. M., Fallon, K. B., Farlow, M. R., Ferris, S., Frosch, M. P., Galasko, D. R., Ganguli, M., Gearing, M., Geschwind, D. H., Ghetti, B., Gilbert, J. R., Glass, J. D., Growdon, J. H., Hamilton, R. L., Harrell, L. E., Head, E., Honig, L. S., Hulette, C. M., Hyman, B. T., Jicha, G. A., Jin, L. - W., Karydas, A., Kaye, J. A., Kim, R., Koo, E. H., Kowall, N. W., Kramer, J. H., LaFerla, F. M., Lah, J. J., Leverenz, J. B., Levey, A. I., Li, G., Lieberman, A. P., Lin, C. - F., Lopez, O. L., Lyketsos, C. G., Mack, W. J., Martiniuk, F., Mash, D. C., Masliah, E., McCormick, W. C., McCurry, S. M., McDavid, A. N., McKee, A. C., Mesulam, M., Miller, B. L., Miller, C. A., Miller, J. W., Murrell, J. R., Olichney, J. M., Pankratz, V. S., Parisi, J. E., Paulson, H. L., Peskind, E., Petersen, R. C., Pierce, A., Poon, W. W., Potter, H., Quinn, J. F., Raj, A., Raskind, M., Reisberg, B., Ringman, J. M., Roberson, E. D., Rosen, H. J., Rosenberg, R. N., Sano, M., Schneider, L. S., Seeley, W. W., Smith, A. G., Sonnen, J. A., Spina, S., Stern, R. A., Tanzi, R. E., Thornton-Wells, T. A., Trojanowski, J. Q., Troncoso, J. C., Valladares, O., Van Deerlin, V. M., Van Eldik, L. J., Vardarajan, B. N., Vinters, H. V., Vonsattel, J. Paul, Weintraub, S., Welsh-Bohmer, K. A., Williamson, J., Wishnek, S., Woltjer, R. L., Wright, C. B., Younkin, S. G., Yu, C. - E., and Yu, L., Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study., JAMA Neurol, vol. 71, no. 11, pp. 1394-404, 2014.
H. - C. Tai, Wang, B. Y., Serrano-Pozo, A., Frosch, M. P., Spires-Jones, T. L., and Hyman, B. T., Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease., Acta Neuropathol Commun, vol. 2, p. 146, 2014.

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